ArticleScience translational medicine2019
Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Sublethal DNA damage switches off B cell effector programs in an RA-FLS-PBMC co-culture.Cell death discovery · 2026Article
- Genotoxic stressors mimicking synovial microenvironment modulate B cell fate in RA-FLS co-culture.Frontiers in immunology · 2026Article
- Association of DNA damage response pathway genes with rheumatoid arthritis risks: a case-control study.Scientific reports · 2025Article
- Identification and validation of biomarkers related to ferroptosis in idiopathic pulmonary fibrosis.Scientific reports · 2025Article
- Bioinformatics screening and clinical validation of CircRNA and related miRNA in male osteoporosis.BMC musculoskeletal disorders · 2025Article
- DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation.Life medicine · 2025Article
- Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia.Frontiers in neurology · 2024Article
- Inhibition of Toll-Like Receptor 4 Signaling Pathway Accelerates the Repair of Avascular Necrosis of Femoral Epiphysis through Regulating Macrophage Polarization in Perthes Disease.Tissue engineering and regenerative medicine · 2023Article
- Review
- ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus.Science advances · 2022Article
- Splenectomy modulates the immune response but does not prevent joint inflammation in a mouse model of RA.Clinical and experimental immunology · 2022Article
- Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen-Specific Clones.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Positive and negative selection shape the human naive B cell repertoire.The Journal of clinical investigation · 2022Article
- RNA Editing-Associated Post-Transcriptional Gene Regulation in Rheumatoid Arthritis.Bioinformatics and biology insights · 2022Article
- Decreased ATM Function Causes Delayed DNA Repair and Apoptosis in Common Variable Immunodeficiency Disorders.Journal of clinical immunology · 2021Article
- DNA Damage Response in the Adaptive Arm of the Immune System: Implications for Autoimmunity.International journal of molecular sciences · 2021Review
- Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.Arthritis research & therapy · 2021Article
- A Panoply of Rheumatological Manifestations in Patients with GATA2 Deficiency.Scientific reports · 2020Review
- Increased Expression of PPAR-γ Modulates Monocytes Into a M2-Like Phenotype in SLE Patients: An Implicative Protective Mechanism and Potential Therapeutic Strategy of Systemic Lupus Erythematosus.Frontiers in immunology · 2020Article
- Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies.Immunological reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Kofi A MensahSection of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-5822-4707
Jeff W ChenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-3371-7820
Jean-Nicolas SchickelDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Isabelle IsnardiNovartis Institute for Biomedical Research, Basel, Switzerland.
Natsuko YamakawaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0001-8388-9527
Andrea Vega-LozaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Jennifer H AnolikDivision of Rheumatology, Allergy, and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Richard A GattiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Erwin W GelfandDepartment of Pediatrics, National Jewish Health, University of Colorado, Denver, CO 80113, USA.
Ruth R MontgomerySection of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-8661-4454
Mark C HorowitzDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06511, USA.
Joe E CraftSection of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-1368-6756
Eric MeffreSection of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA. eric.meffre@yale.edu.ORCID 0000-0003-4326-0171
Yale University · USNational Jewish Health · USNovartis (Switzerland) · CHUniversity of California, Los Angeles · USUniversity of Rochester · US
Funding
Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8MTRAINING PROGRAM IN INVESTIGATIVE RHEUMATOLOGYT32AR007107 · NIAMS · YALE UNIVERSITY · PI RICHARD J BUCALA · 1986 to 2026
$7.5MIMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4MLoss of B Cell Tolerance in Rheumatoid ArthritisR01AI071087 · NIAID · YALE UNIVERSITY · PI MEFFRE, ERIC · 2006 to 2016
$4.3MMOLECULAR CHARACTERIZATION OF THE SNRNP POLYPEPTIDESR01AR040072 · NIAMS · YALE UNIVERSITY · PI Joseph Edgar Craft · 1990 to 2026
$2.5MNIAID NIH HHS HHSN272201100019CNIAID NIH HHS HHSN272201100019INIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI071087NIAMS NIH HHS R01 AR040072NIAMS NIH HHS R37 AR040072NIAMS NIH HHS T32 AR007107
Abstract
Patients with rheumatoid arthritis (RA) may display atypical CD21
Indexed as
AnimalsArthritis, RheumatoidAtaxia Telangiectasia Mutated ProteinsB-LymphocytesBone DensityBone ResorptionCell SurvivalHumansImmunoglobulinsJointsLymphocyte CountMiceMiddle AgedOsteogenesisOsteoprotegerinPhenotypeAtaxia Telangiectasia Mutated ProteinsIgKImmunoglobulinsOsteoprotegerinRANK LigandReceptors, Complement 3d
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.