ArticleScience translational medicine2019
Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 94 citations in OpenAlex.
- Lymphocyte-mediated immune responses to Leishmania infection.Nature reviews. Immunology · 2026Review
- Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body.Nature biotechnology · 2026Article
- Article
- Systemic IgG responses toFrontiers in immunology · 2026Article
- Temporal transcriptional dynamics in cutaneous leishmaniasis reveal novel targets for therapeutic interventions in a dermal mouse model.Frontiers in immunology · 2026Article
- Response and therapeutic failure to meglumine antimoniate, the first-line drug for cutaneous leishmaniasis infections in Colombian soldiers.Parasitology research · 2025Article
- Hypoxia and IL-15 Cooperate to Induce Perforin Expression by CD8 T Cells and Promote Damage to the Skin in Murine Cutaneous Leishmaniasis.The Journal of investigative dermatology · 2025Article
- Immunomodulatory and regenerative effects of human umbilical cord MSC-EVs in Cutaneous Leishmaniasis.Stem cell research & therapy · 2025Article
- Review
- Circulating Soluble Factors and T-Cell Subsets as Immunological Predictors of Therapy Response in Human Cutaneous Leishmaniasis.The Journal of infectious diseases · 2025Article
- Oxygen and immunity toInfection and immunity · 2025Review
- Genetic analysis of IFNG-AS1 implicates opposite effects to Leishmania guyanensis-cutaneous leishmaniasis: rs4913269 confers protection while rs7134599 enhances susceptibility and correlates with high plasma IL-4 and IL-10 levels.PLoS neglected tropical diseases · 2025Article
- IL-32-producing CD8+ memory T cells define immunoregulatory niches in human cutaneous leishmaniasis.The Journal of clinical investigation · 2025Article
- Innate biosignature of treatment failure in human cutaneous leishmaniasis.Nature communications · 2025Article
- Comparative gene expression pattern of immune-related genes using dual-color RT-MLPA in the lesions of cutaneous leishmaniasis caused by L. major and L. tropica.PLoS neglected tropical diseases · 2025Article
- A Quantitative Polymerase Chain Reaction (qPCR) Protocol Predictive of Treatment Outcome in Cutaneous Leishmaniasis Caused byOpen forum infectious diseases · 2025Article
- Senescence-related genes are associated with the immunopathology signature of American tegumentary leishmaniasis lesions and may predict progression to mucosal leishmaniasis.Clinical and experimental immunology · 2025Article
- Annexin A1 downregulatesFrontiers in immunology · 2025Article
- Predicting clinical outcomes at hospital admission of patients with COVID-19 pneumonia using artificial intelligence: a secondary analysis of a randomized clinical trial.Frontiers in medicine · 2025Article
- Chemokines Signature and T Cell Dynamics in Leishmaniasis: Molecular insight and therapeutic application.Expert reviews in molecular medicine · 2024Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Camila Farias AmorimDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, PA 19104-4539, USA.ORCID 0000-0001-8249-7265
Fernanda O NovaisDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, PA 19104-4539, USA.ORCID 0000-0002-9491-0384
Ba T NguyenDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, PA 19104-4539, USA.ORCID 0000-0002-8481-5471
Ana M MisicDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, PA 19104-4539, USA.ORCID 0000-0002-4645-3895
Lucas P CarvalhoServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia 40110-060, Brazil.
Edgar M CarvalhoServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia 40110-060, Brazil.
Daniel P BeitingDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, PA 19104-4539, USA. beiting@upenn.edu pscott@upenn.edu.ORCID 0000-0002-2865-4589
Phillip ScottDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, PA 19104-4539, USA. beiting@upenn.edu pscott@upenn.edu.ORCID 0000-0001-8732-0653
University of Pennsylvania · USComplexo Hospitalar Universitário Professor Edgard Santos · BR
Funding
The role of Leishmania braziliensis strain polymorphism on disease outcome and ..P50AI030639 · NIAID · FEDERAL UNIVERSITY OF BAHIA · PI CARVALHO, EDGAR M · 1991 to 2023
$9.1MStudy Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6MSkin microbiome contributions to the pathogenesis of cutaneous leishmaniasisR01AI143790 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, PHILLIP SCOTT · 2019 to 2026
$6.0MThe Role of Innate Cells in the Pathogenesis of Leishmania Braziliensis InfectionU01AI088650 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SCOTT, PHILLIP · 2011 to 2019
$4.3MInflammation in the Pathogenesis of Disseminated LeishmaniasisU01AI136032 · NIAID · FEDERAL UNIVERSITY OF BAHIA · PI CARVALHO, EDGAR M · 2017 to 2021
$1.6MParasite polymorphism and host immune response in cutaneous leishmaniasis outcomeR01AI136862 · NIAID · FEDERAL UNIVERSITY OF BAHIA · PI CARVALHO, LUCAS P, SCOTT, PHILLIP · 2018 to 2022
$593kNIAID NIH HHS P50 AI030639NIAID NIH HHS R01 AI136862NIAID NIH HHS R01 AI143790NIAID NIH HHS U01 AI088650NIAID NIH HHS U01 AI136032NIAMS NIH HHS P30 AR069589
Abstract
Patients infected with
Indexed as
Gene Expression RegulationParasite LoadCD8-Positive T-LymphocytesCell DeathGene Expression ProfilingHumansKiller Cells, NaturalLeishmania braziliensisLeishmaniasis, CutaneousSkinTreatment Outcome
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.