ArticleScience translational medicine2019
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Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates.Journal of virology · 2026Article
- Coadministration of rapamycin with a DNA/MVA SIV vaccine improves memory CD8+ T cell response.JCI insight · 2026Article
- Challenges in the Vaccination of HIV-Infected Individuals.Vaccines · 2025Review
- ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primates.NPJ vaccines · 2025Article
- Nanoengineered-based delivery systems to modulate CD4Frontiers in pharmacology · 2025Review
- Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine.Frontiers in immunology · 2025Article
- Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques.Nature communications · 2023Article
- A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses.Science translational medicine · 2023Article
- Editorial: CD4+ T cells in HIV: A Friend or a Foe?Frontiers in immunology · 2023Article
- A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.Science immunology · 2022Article
- Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A*01 negative Rhesus Macaques.Frontiers in immunology · 2022Article
- Vaccine targeting SIVmac251 protease cleavage sites protects macaques against vaginal infection.The Journal of clinical investigation · 2020Article
- Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome.Journal of virology · 2020Article
- CD4Vaccines · 2020Article
- CD8Nature reviews. Immunology · 2020Review
- T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.Nature medicine · 2020Article
- A Novel Immunogen Selectively Eliciting CD8Journal of virology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 4 institutions in 2 countries.
Venkateswarlu ChamchaEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0003-4784-3526
Pradeep B J ReddyEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0002-0406-4701
Sunil KannanganatEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0003-4605-9799
Courtney WilkinsDepartment of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.
Sailaja GangadharaEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0001-8603-628X
Vijayakumar VeluEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0003-4238-1924
Richard GreenDepartment of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.
G Lynn LawDepartment of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.ORCID 0000-0003-2820-7428
Jean ChangDepartment of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.ORCID 0000-0002-1268-2251
James R BowenEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Pamela A KozlowskiDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Michelle LiftonHarvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Sampa SantraHarvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Traci LegereEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0001-6393-719X
Lynette S CheaEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Lakshmi ChennareddiEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Tianwei YuDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.
Mehul S SutharEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0002-2686-8380
Guido SilvestriEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0001-6602-2470
Cynthia A DerdeynEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Michael GaleDepartment of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.ORCID 0000-0002-6332-7436
Francois VillingerEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Eric HunterEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0002-4273-8631
Rama Rao AmaraEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. ramara@emory.edu.ORCID 0000-0002-6309-6797
Emory University · USImmune Regulation (United Kingdom) · GBBeth Israel Deaconess Medical Center · USLouisiana State University Health Sciences Center New Orleans · US
Funding
Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8MNational Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MYerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WESTMORELAND, SUSAN V. · 1985 to 2011
$139.3MUniversity of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9MVirology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0MB and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection - Administrative SupplementUM1AI124436 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO, HUNTER, ERIC · 2016 to 2021
$42.3MRole of Follicular T Helper Cells In Enhancing Humoral Immunity and ProtectionU19AI096187 · NIAID · EMORY UNIVERSITY · PI DERDEYN, CYNTHIA ANN · 2011 to 2015
$26.5MTargeting mTOR to Enhance Immunogenicity and Efficacy of HIV VaccinesP01AI088575 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO · 2010 to 2013
$11.4MPreclinical Studies and T cell ResponsesU19AI109633 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO · 2014 to 2018
$10.2MMOUSE MODELS OF CANCER, BONE DISEASE, AND LACTATIONK26RR000168 · NCRR · OHIO STATE UNIVERSITY · PI ROSOL, THOMAS J · 2000 to 2004
$547kNCRR NIH HHS K26 RR000168NCRR NIH HHS P51 RR000168NIAID NIH HHS HHSN272201300010CNIAID NIH HHS HHSN272201300010INIAID NIH HHS P01 AI088575NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI050409NIAID NIH HHS U19 AI096187NIAID NIH HHS U19 AI109633NIAID NIH HHS UM1 AI124436NIH HHS P51 OD010425NIH HHS P51 OD011107NIH HHS P51 OD011132
Abstract
Activated CD4 T cells are a major target of HIV infection. Results from the STEP HIV vaccine trial highlighted a potential role for total activated CD4 T cells in promoting HIV acquisition. However, the influence of vaccine insert-specific CD4 T cell responses on HIV acquisition is not known. Here, using the data obtained from four macaque studies, we show that the DNA prime/modified vaccinia Ankara boost vaccine induced interferon γ (IFNγ
Indexed as
AnimalsAntibodies, ViralAntibody FormationCD8-Positive T-LymphocytesColonFemaleGene Expression ProfilingInterferon-gammaLymphocyte CountMacaca mulattaMaleMucous MembraneReceptors, CCR5SAIDS VaccinesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAntibodies, ViralInterferon-gammaReceptors, CCR5SAIDS Vaccines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.