Evidence map›Paper›PMID 31747972›Full record

SynthesisAIDS research and therapy2019

Kidney transplant outcomes in HIV-positive patients: a systematic review and meta-analysis.

Xin Zheng, Lian Gong, Wenrui Xue, Song Zeng, Yue Xu, Yu Zhang, Xiaopeng Hu

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in AIDS research and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Pancreas transplant outcomes in patients with human immunodeficiency virus infection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Trends over Time in Practice and Outcomes of Lung Transplantation in Recipients With Human Immunodeficiency Virus.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xin ZhengUrology Institute, Capital Medical University, Beijing, China.
Lian GongUrology Institute, Capital Medical University, Beijing, China.
Wenrui XueDepartment of Urology, Beijing You-An Hospital, Capital Medical University, Beijing, China.
Song ZengUrology Institute, Capital Medical University, Beijing, China.
Yue XuUrology Institute, Capital Medical University, Beijing, China.
Yu ZhangDepartment of Urology, Beijing You-An Hospital, Capital Medical University, Beijing, China.
Xiaopeng HuUrology Institute, Capital Medical University, Beijing, China. xiaopeng_hu@sina.com.
Capital Medical University · CNBeijing Chaoyang Emergency Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplantation is now a viable alternative to dialysis in HIV-positive patients who achieve good immunovirological control with the currently available antiretroviral therapy regimens. This systematic review and meta-analysis investigate the published evidence of outcome and risk of kidney transplantation in HIV-positive patients following the PRISMA guidelines.

methodsSearches of PubMed, the Cochrane Library and EMBASE identified 27 cohort studies and 1670 case series evaluating the survival of HIV-positive kidney transplant patients published between July 2003 and May 2018. The regimens for induction, maintenance therapy and highly active antiretroviral therapy, acute rejection, patient and graft survival, CD4 count and infectious complications were recorded. We evaluated the patient survival and graft survival at 1 and 3 years respectively, acute rejection rate and also other infectious complications by using a random-effects analysis.

resultsAt 1 year, patient survival was 0.97 (95% CI 0.95; 0.98), graft survival was 0.91 (95% CI 0.88; 0.94), acute rejection was 0.33 (95% CI 0.28; 0.38), and infectious complications was 0.41 (95% CI 0.34; 0.50), and at 3 years, patient survival was 0.94 (95% CI 0.90; 0.97) and graft survival was 0.81 (95% CI 0.74; 0.87).

conclusionsWith careful selection and evaluation, kidney transplantation can be performed with good outcomes in HIV-positive patients.

Indexed as

Graft SurvivalAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountGraft RejectionHIV InfectionsHIV SeropositivityHumansKidney TransplantationTreatment Outcome

Identifiers

PMID31747972
PMCPMC6868853
OpenAlexW2990796438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.