Evidence map›Paper›PMID 31747885›Full record

ArticleBMC surgery2019

Evaluation of D2-plus radical resection for gastric cancer with pyloric invasion.

Zhi-Yuan Xu, Can Hu, Shangqi Chen, Yi-An Du, Ling Huang, Peng-Fei Yu, Li-Jing Wang, Xiang-Dong Cheng

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01836991 (Phase 2 Study of D2 and D2+ Radical Surgery for the Treatment of Advanced Distal Gastric Cancer), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01836991 phase2unknown statusnot on this map

Phase 2 Study of D2 and D2+ Radical Surgery for the Treatment of Advanced Distal Gastric Cancer

TypeinterventionalSponsorZhejiang Cancer HospitalRan2012 to 2017Enrolled200ConditionsGastric CancerArmssurgery
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Japanese gastric cancer treatment guidelines 2025 (7th edition).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Guideline
  2. Current clinical trials on gastric cancer surgery in China.World journal of gastrointestinal oncology · 2024
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhi-Yuan XuDepartment of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Can HuZhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Shangqi ChenZhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Yi-An DuDepartment of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Ling HuangDepartment of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Peng-Fei YuDepartment of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Li-Jing WangDepartment of Ultrasonics, The Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Xiang-Dong ChengDepartment of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China. chengxd@zcmu.edu.cn.ORCID http://orcid.org/0000-0002-8687-8310

Funding

Key Research Program of Traditional Chinese medical Science and Technology Plan of Zhejiang Province 2016ZZ012Medical Science and Technology Project of Zhejiang Province Nos.WKJ-ZJ-1728, Nos.2016KYB220Natural Science Foundation of Zhejiang Province Nos.LY16H280011, Nos.LY18H290006
6 · The paper itself

Abstract

backgroundThe optimal lymphadenectomy for gastric cancer (GC) with pyloric invasion is controversial because the pattern of lymph node metastasis is different from that of distal GC. The rate of lymph node metastasis into the posterior area of the pancreatic head and hepatoduodenal ligament is high. This study evaluated the estimated benefit of radical gastrectomy with D2-plus lymphadenectomy in patients with pyloric invasion.

methodsAll patients with GC invading the pylorus who underwent curative surgical resection with D2-plus lymphadenectomy between February 2013 and September 2015 were enrolled in the study. The index of estimated benefit from lymph node dissection (IEBLD) was calculated by multiplying the incidence of metastasis to each lymph node station by the 3-year overall survival (OS) rate of patients with metastasis to that station.

resultsIn total, 128 patients were eligible. The rate of lymph node metastasis and the 3-year OS rate (and IEBLD) of the patients with metastasis to lymph nodes were 14.3 and 44.4% (5.56) for No. 8p, 10.9 and 35.7% (3.89) for No. 12b, 9.5 and 33.3% (3.13) for No. 12p, 18.8 and 54.2% (10.19) for No. 13, and 21.8 and 53.6% (11.68) for No. 14v, respectively.

conclusionsIn radical gastrectomy for GC with pyloric invasion, some survival benefit was observed with dissection of the No. 13 and No. 14 lymph nodes, but there was no survival benefit with dissection of the No. 8p lymph nodes. The No. 12b and No. 12p lymph nodes may be better to dissect in cT3 GC patients with pyloric invasion.

trial registrationhttp://ClinicalTrials.gov Identifier: NCT01836991. Date of registration: April 17, 2013.

Indexed as

AdultAgedFemaleGastrectomyHumansLymphatic MetastasisLymph Node ExcisionLymph NodesMaleMiddle AgedPancreasProspective StudiesPylorusStomach NeoplasmsSurvival RateAdvanced gastric cancerD2-plus lymphadenectomyPylorus invasion

Identifiers

PMID31747885
PMCPMC6868836

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.