Evidence map›Paper›PMID 31747874›Full record

ReviewThe journal of headache and pain2019

Functional connectivity studies in migraine: what have we learned?

Kirill Skorobogatykh, Willem Sebastiaan van Hoogstraten, Diana Degan, Anastasia Prischepa, Anastasya Savitskaya, Biondo Michela Ileen, Enrico Bentivegna, Iaroslav Skiba, Laura D'Acunto, Livia Ferri and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. Aberrant Spontaneous Low-Frequency Brain Activity in Migraine: A Meta-Analysis of Resting-State fMRI Studies.Journal of neuroimaging : official journal of the American Society of Neuroimaging
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  20. Psychopathological variables in chronic migraine patients with different therapeutic approach: psychological profile differences and impact on therapeutic efficacy in real life.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kirill SkorobogatykhUniversity Headache Clinic, Moscow, Russia.
Willem Sebastiaan van HoogstratenDepartment of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Diana DeganDepartment of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Anastasia PrischepaDepartment of Neurology, Sechenov University, Moscow, Russia.
Anastasya SavitskayaDepartment of Neurology, Sechenov University, Moscow, Russia.
Biondo Michela IleenSapienza University of Rome, Rome, Italy.
Enrico BentivegnaInternal Medicine Unit, Sant' Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Iaroslav SkibaNeurology Department, Military Medical Academy, St. Petersburg, Russia.
Laura D'AcuntoClinical Unit of Neurology, Department of Medical Sciences, University Hospital and Health Services of Trieste, University of Trieste, Trieste, Italy.
Livia FerriInternal Medicine Unit, Sant' Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Simona SaccoClinical Neurology Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Jakob Møller HansenDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Valdemar Hansens Vej 5, Glostrup, 2600, Copenhagen, Denmark.
Faisal Mohammad AminDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Valdemar Hansens Vej 5, Glostrup, 2600, Copenhagen, Denmark. faisal@dadlnet.dk.
European Headache Federation School of Advanced Studies (EHF-SAS)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResting-state functional connectivity (FC) MRI has widely been used to understand migraine pathophysiology and to identify an imaging marker of the disorder. Here, we review what we have learned from FC studies.

methodsWe performed a literature search on the PubMed website for original articles reporting data obtained from conventional resting-state FC recording in migraine patients compared with healthy controls or during and outside of migraine attacks in the same patients.

resultsWe found 219 articles and included 28 in this review after screening for inclusion and exclusion criteria. Twenty-five studies compared migraine patients with healthy controls, whereas three studies investigated migraine patients during and outside of attacks. In the studies of interictal migraine more alterations of more than 20 FC networks (including amygdala, caudate nucleus, central executive, cerebellum, cuneus, dorsal attention network, default mode, executive control, fronto-parietal, hypothalamus, insula, neostriatum, nucleus accumbens, occipital lobe, periaqueductal grey, prefrontal cortex, salience, somatosensory cortex I, thalamus and visual) were reported. We found a poor level of reproducibility and no migraine specific pattern across these studies.

conclusionBased on the findings in the present review, it seems very difficult to extract knowledge of migraine pathophysiology or to identify a biomarker of migraine. There is an unmet need of guidelines for resting-state FC studies in migraine, which promote the use of homogenous terminology, public availability of protocol and the a priori hypothesis in line with for instance randomized clinical trial guidelines.

Indexed as

AdultAmygdalaCerebral CortexFemaleHumansHypothalamusMagnetic Resonance ImagingMaleMigraine DisordersPrefrontal CortexReproducibility of ResultsThalamusFunctional connectivityHeadacheMigraineNeuroimagingResting-state fMRI

Identifiers

PMID31747874
PMCPMC6868768

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.