Evidence map›Paper›PMID 31747864›Full record

Trial reportJournal of the American Heart Association2019

Remote Ischemic Conditioning After Stroke Trial 2: A Phase IIb Randomized Controlled Trial in Hyperacute Stroke.

Timothy J England, Amanda Hedstrom, Saoirse E O'Sullivan, Lisa Woodhouse, Ben Jackson, Nikola Sprigg, Philip M Bath

Registry-linked trialAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06473207 (Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest), which is not on this map. Cited by 39 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06473207 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest : a Randomized Open Label Controlled Trial

TypeinterventionalSponsorCentre Hospitalier Intercommunal de Toulon La Seyne sur MerRan2025 to 2028Enrolled48ConditionsOut-Of-Hospital Cardiac ArrestArmsRemote ischemic post conditioning sessions, Sham sessions
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Remote ischaemic conditioning for preventing and treating ischaemic stroke.The Cochrane database of systematic reviews · 2025
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  9. A meta-analysis of remote ischaemic conditioning in experimental stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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  15. The effect of repeated remote ischemic postconditioning after an ischemic stroke (REPOST): A randomized controlled trial.International journal of stroke : official journal of the International Stroke Society · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Timothy J EnglandVascular Medicine Division of Medical Sciences and GEM School of Medicine University of Nottingham Derby United Kingdom.
Amanda HedstromVascular Medicine Division of Medical Sciences and GEM School of Medicine University of Nottingham Derby United Kingdom.
Saoirse E O'SullivanVascular Medicine Division of Medical Sciences and GEM School of Medicine University of Nottingham Derby United Kingdom.
Lisa WoodhouseStroke Trials Unit Division of Clinical Neuroscience City Hospital Campus University of Nottingham Nottingham United Kingdom.
Ben JacksonStroke Trials Unit Division of Clinical Neuroscience City Hospital Campus University of Nottingham Nottingham United Kingdom.
Nikola SpriggStroke Trials Unit Division of Clinical Neuroscience City Hospital Campus University of Nottingham Nottingham United Kingdom.
Philip M BathStroke Trials Unit Division of Clinical Neuroscience City Hospital Campus University of Nottingham Nottingham United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Repeated episodes of limb ischemia and reperfusion (remote ischemic conditioning [RIC]) may protect the brain from ischemic reperfusion injury. Methods and Results We performed a phase IIb blinded dose-escalation sham-controlled trial in patients with hyperacute stroke, randomized 1:1 to receive RIC (four 5-minute cycles) or sham to the nonparetic upper limb, in 3 blocks of increasing dose, starting within 6 hours of ictus. The primary outcome was trial feasibility (recruitment, attrition). Secondary outcomes included adherence, tolerability, safety (serious adverse events), plasma biomarkers at days 1 and 4 (S100-ß protein, matrix metalloproteinase-9, and neuron-specific enolase), and functional outcome. Sixty participants were recruited from 2 centers (3 per month) with no loss to follow-up: time to randomization 4 hours 5 minutes (SD 72 minutes), age 72 years (12), men 60%, blood pressure 154/80 mm Hg (25/12), National Institutes of Health Stroke Scale 8.4 (6.9), and 55% thrombolyzed. RIC was well tolerated with adherence not differing between RIC and sham, falling in both groups on day 3 (

Indexed as

Ischemic PostconditioningAgedAged, 80 and overFemaleHumansMaleMiddle AgedSingle-Blind MethodStrokeTime Factorsfeasibilityrandomized controlled trialremote ischemic conditioningstroke

Identifiers

PMID31747864
PMCPMC6912955

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.