ArticleCirculation2020
Cumulative Blood Pressure Exposure During Young Adulthood and Mobility and Cognitive Function in Midlife.
Article in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Cumulative blood pressure and risk of dementia and cognitive decline: a systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Self-management in young and middle-aged patients with hypertension: a systematic review and meta-synthesis of qualitative studies.Systematic reviews · 2024Pooled it
- Article
- Metabolic parameter variability, brain structure, perfusion, and cognition: a population-based study.Alzheimer's research & therapy · 2026Article
- Methodological and Statistical Considerations in Assessing the Association Between Cumulative Blood Pressure and Cognitive Decline.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Prospective observational study of brain magnetic resonance imaging in adolescents with primary hypertension.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Elevated Cumulative Blood Pressure is Associated With Cognitive Decline: A Nationwide Population-Based Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Cumulative blood pressure exposure and cognition: the potential mediating role of brain volume.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Cumulative lipid exposure in young adulthood and risk of midlife MASLD.JHEP reports : innovation in hepatology · 2026Article
- Cumulative Blood Pressure as a Marker of Early Cognitive Decline.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Magnetic resonance spectroscopy study of cognitive impairment associated with cerebral small vessel disease.Brain imaging and behavior · 2026Article
- The Role of Rho-associated Kinase in the Cognitive Benefits of the ACE Inhibitory Peptide LAP for Hypertension.Current molecular medicine · 2026Article
- Early-life blood pressure and midlife brain and cognitive health: tests in two birth cohorts.Brain communications · 2026Article
- Time-averaged cumulative pulse pressure in midlife and incident atrial fibrillation: the atherosclerosis risk in communities study.Journal of human hypertension · 2026Article
- Temporal Proteomic Remodeling of Cerebral Arteries in Male Hypertensive Rats.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population.Annals of medicine · 2025Article
- The relationship between blood pressure and cognitive decline differs by race.The Gerontologist · 2025Article
- Association between cumulative blood pressure and the risk of cognitive impairment in Chinese older adults: a longitudinal study over 16 years.BMC geriatrics · 2025Article
- Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline.Journal of the American Heart Association · 2025Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHigh blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife. Furthermore, we tested whether these associations were modified by cerebral white matter hyperintensity (WMH) burden.
methodsWe included 191 participants from the CARDIA study (Coronary Artery Risk Development in Young Adults), a community-based cohort of young individuals followed over 30 years. Cumulative BP was calculated as the area under the curve (mm Hg×years) from baseline up to year 30 examination. Gait and cognition were assessed at the year 30 examination. Cerebral WMH was available at year 30 in a subset of participants (n=144) who underwent magnetic resonance imaging. Multiple linear regression models were used to assess the association of cumulative BP exposure with gait and cognition. To test effect modification by WMH burden, participants were stratified at the median of WMH and tested for interaction.
resultsHigher cumulative systolic and diastolic BPs were associated with slower walking speed (both
conclusionsExposure to higher BP levels from young to midlife is associated with worse gait and cognitive performance in midlife. Furthermore, WMH moderates the association of cumulative BP exposure with gait, but not with cognitive function in midlife. The mechanisms underpinning the impact of BP exposure on brain structure and function must be investigated in longitudinal studies using a life course approach.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.