ArticleNature2019
A new antibiotic selectively kills Gram-negative pathogens.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 380 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
380citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
380 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Drug-resistantClinical microbiology reviews · 2025Pooled it
- BamA as a next-generation antibacterial target: mechanistic insights, inhibitor landscape, and rational drug design strategies.RSC advances · 2026Review
- Predicting resistance evolution to guide antibiotic development.Nature reviews. Microbiology · 2026Review
- Saikosaponin D Attenuates Postherpetic Neuralgia and Reduces Inflammation by Regulating Gut Microbiota in a Rodent Model.Biochemical genetics · 2026Article
- Deep learning-driven de novo discovery of binders targeting the transmembrane domain of BamA.Archives of microbiology · 2026Article
- Total Synthesis and Structural Revision of Rhabdobranin Reveals a Cryptic Gram-Negative Antibiotic.Journal of the American Chemical Society · 2026Article
- A Machine Learning-Based Genome Mining Approach Reveals Unprecedented Biarylitide Diversity.JACS Au · 2026Article
- Reprogramming RiPP scaffolds through skeletal editing unlocks chemical space.Chemical science · 2026Article
- Quantifying outer membrane permeability to β-lactam antibiotics using outer membrane vesicles that protect antibiotic-susceptible bacteria.Nature communications · 2026Article
- Unified Access to Biaryl-Bridged Linkages Unlocks Structural Diversification of Noncanonical Cyclic Peptides.Journal of the American Chemical Society · 2026Article
- Next-Generation Strategies to Encounter Antimicrobial Resistance (AMR): From Lariocidin to Gene Editing and Nanotechnology-Based Approaches.Molecules (Basel, Switzerland) · 2026Review
- L-type pyocins inhibit the BAM complex to kill without cell entry.Nature communications · 2026Article
- Deep-learning-based virtual screening of antibacterial compounds.Nature biotechnology · 2026Article
- Article
- Monitoring Membrane Protein Folding Assisted by Insertases and Translocases Using AFM-Based Single-Molecule Force Spectroscopy.Chemical reviews · 2026Review
- Multiplexing antibiotic screening assay in droplet microfluidics.Scientific reports · 2026Article
- A mechanism for substrate quality control in outer membrane protein assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- P450 Cyptide Synthase AscB Catalyzes Fused Cyclophane at the YxWxH Motif on the Precursor Peptides.Organic letters · 2026Article
- Discovery of HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Burn Infections and Sepsis: Challenges and Future Prospects of Antibacterial Therapy.Antibiotics (Basel, Switzerland) · 2026Review
320 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
30 authors.
Yu ImaiAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Kirsten J MeyerAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Akira IinishiAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Quentin Favre-GodalAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Robert GreenAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Sylvie ManuseAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Mariaelena CaboniAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Miho MoriAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Samantha NilesAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Meghan GhiglieriAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Chandrashekhar HonraoCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Xiaoyu MaCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Jason J GuoCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Alexandros MakriyannisCenter for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Luis Linares-OtoyaInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany.
Nils BöhringerInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany.
Zerlina G WuisanInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany.
Hundeep KaurBiozentrum, University of Basel, Basel, Switzerland.
Runrun WuPurdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN, USA.
André MateusGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Athanasios TypasGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Mikhail M SavitskiGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Josh L EspinozaDepartment of Human Biology, J. Craig Venter Institute, La Jolla, CA, USA.
Aubrie O'RourkeDepartment of Human Biology, J. Craig Venter Institute, La Jolla, CA, USA.
Karen E NelsonDepartment of Human Biology, J. Craig Venter Institute, La Jolla, CA, USA.
Sebastian HillerBiozentrum, University of Basel, Basel, Switzerland.
Nicholas NoinajPurdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Till F SchäberleInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany.
Anthony D'OnofrioAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
Kim LewisAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA. k.lewis@neu.edu.
Funding
Uncultured bacteria for the discovery of novel antimicrobialsP01AI118687 · NIAID · NORTHEASTERN UNIVERSITY · PI LEWIS, KIM · 2016 to 2020
$8.9MStructural Characterization of the TOC Protein Translocon MachineryR01GM127896 · NIGMS · PURDUE UNIVERSITY · PI NOINAJ, NICHOLAS · 2018 to 2022
$1.5MUnraveling the mechanism by which the BAM complex mediates OMP biogenesisR01GM127884 · NIGMS · PURDUE UNIVERSITY · PI NOINAJ, NICHOLAS · 2019 to 2022
$1.2MNIAID NIH HHS P01 AI118687NIGMS NIH HHS R01 GM127884NIGMS NIH HHS R01 GM127896NIH HHS GM127884NIH HHS GM127896
Abstract
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens
Indexed as
AnimalsAnti-Bacterial AgentsBacterial Outer Membrane ProteinsCell LineDisease Models, AnimalDrug DiscoveryDrug Resistance, MicrobialEscherichia coli ProteinsFemaleGastrointestinal MicrobiomeGram-Negative BacteriaHumansMiceMicrobial Sensitivity TestsMicrobial ViabilityMutationAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBamA protein, E colidarobactinEscherichia coli ProteinsPhenylpropionates
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.