Evidence map›Paper›PMID 31747670›Full record

ArticleHormone research in paediatrics2019

Absence of Testicular Adrenal Rest Tumors in Newborns, Infants, and Toddlers with Classical Congenital Adrenal Hyperplasia.

Mimi S Kim, Christina M Koppin, Pankhuri Mohan, Fariba Goodarzian, Heather M Ross, Mitchell E Geffner, Roger De Filippo, Paul Kokorowski

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormone research in paediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mimi S KimCenter for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, California, USA, mskim@chla.usc.edu.
Christina M KoppinCenter for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, California, USA.
Pankhuri MohanCenter for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, California, USA.
Fariba GoodarzianKeck School of Medicine of University of Southern California, Los Angeles, California, USA.
Heather M RossCenter for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, California, USA.
Mitchell E GeffnerCenter for Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, California, USA.
Roger De FilippoKeck School of Medicine of University of Southern California, Los Angeles, California, USA.
Paul KokorowskiKeck School of Medicine of University of Southern California, Los Angeles, California, USA.
University of Southern California · USChildren's Hospital of Los Angeles · US

Funding

Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
Brain and Adipose Contributors to Food Seeking in Youth with Adrenal HyperplasiaK23HD084735 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KIM, MIMI SUSAN · 2016 to 2018
$474k
NCATS NIH HHS KL2 TR001854NICHD NIH HHS K23 HD084735
6 · The paper itself

Abstract

introductionTesticular adrenal rest tumors (TART) are a known consequence for males with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. TART are associated with potential infertility in adults. However, little is known about TART in very young males with CAH.

objectiveWe assessed the presence of TART in newborn, infant, and toddler males with classical CAH via scrotal ultrasound.

methodsMales with CAH had scrotal ultrasounds during the first 4 years of life, evaluating testes for morphology, blood flow, and presence of TART. Newborn screen 17-hydroxyprogesterone (17-OHP) and serum 17-OHP at the time of ultrasound were recorded. Bone ages were considered very advanced if ≥2 SD above chronological age.

resultsThirty-one ultrasounds in 16 males were performed. An initial ultrasound was obtained in four newborns at diagnosis (6.8 ± 2.1 days), six infants (2.2 ± 0.9 months), and six toddlers (2.4 ± 0.9 years). Eleven males had at least one repeat ultrasound. A large proportion (11/16) were in poor hormonal control with an elevated 17-OHP (325 ± 298 nmol/L). One infant was in very poor hormonal control (17-OHP 447 nmol/L) at initial ultrasound, and two toddlers had advanced bone ages (+3.2 and +4.5 SD) representing exposure to postnatal androgens. However, no TART were detected in any subjects.

conclusionsTART were not found by scrotal ultrasound in males up to 4 years of age with classical CAH despite settings with expected high ACTH drive. Further research into the occurrence of TART in CAH may elucidate factors that contribute to the detection and individual predisposition to TART.

Indexed as

17-alpha-HydroxyprogesteroneAdrenal Hyperplasia, CongenitalAdrenal Rest TumorChild, PreschoolHumansInfantInfant, NewbornMaleScrotumTesticular NeoplasmsUltrasonography17-alpha-HydroxyprogesteroneAdrenal rest tissueCongenital adrenal hyperplasiaNewbornTestisUltrasonography

Identifiers

PMID31747670
PMCPMC7004842
OpenAlexW2991315412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.