ArticlePLoS genetics2019
East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Review
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- Mutations in the Ferric Uptake Regulator Gene (Microorganisms · 2025Article
- Advances in Helicobacter pylori lipopolysaccharide structure and function.FEMS microbiology reviews · 2025Review
- Strain-Specific Infection of Phage AP1 to Rice Bacterial Brown Stripe PathogenPlants (Basel, Switzerland) · 2024Article
- Article
- Lipopolysaccharide O-antigen profiles of Helicobacter pylori strains from Southwest China.BMC microbiology · 2023Article
- A smooth tubercle bacillus from Ethiopia phylogenetically close to the Mycobacterium tuberculosis complex.Nature communications · 2023Article
- Roles of Lipopolysaccharide Glycosyltransferases in Maintenance ofInternational journal of molecular sciences · 2023Article
- Metagenomic and single-cell RNA-Seq survey of the Helicobacter pylori-infected stomach in asymptomatic individuals.JCI insight · 2023Article
- Review
- Helicobacter pylori binds human Annexins via Lipopolysaccharide to interfere with Toll-like Receptor 4 signaling.PLoS pathogens · 2022Article
- The Effects ofBiomedicines · 2022Article
- Review
- Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori.Nature communications · 2021Article
- Riboregulation in the Major Gastric PathogenFrontiers in microbiology · 2021Review
- Metabolic Glycan Labeling-Based Screen to Identify Bacterial Glycosylation Genes.ACS infectious diseases · 2020Article
- A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region.Nature communications · 2020Article
- Susceptibility-guided bismuth quadruple therapies for resistantPrecision clinical medicine · 2020Article
- Metabolic inhibitors of bacterial glycan biosynthesis.Chemical science · 2020Article
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Authors and funding
23 authors at 5 institutions in 4 countries.
Funding
Abstract
The lipopolysaccharide O-antigen structure expressed by the European Helicobacter pylori model strain G27 encompasses a trisaccharide, an intervening glucan-heptan and distal Lewis antigens that promote immune escape. However, several gaps still remain in the corresponding biosynthetic pathway. Here, systematic mutagenesis of glycosyltransferase genes in G27 combined with lipopolysaccharide structural analysis, uncovered HP0102 as the trisaccharide fucosyltransferase, HP1283 as the heptan transferase, and HP1578 as the GlcNAc transferase that initiates the synthesis of Lewis antigens onto the heptan motif. Comparative genomic analysis of G27 lipopolysaccharide biosynthetic genes in strains of different ethnic origin revealed that East-Asian strains lack the HP1283/HP1578 genes but contain an additional copy of HP1105 and JHP0562. Further correlation of different lipopolysaccharide structures with corresponding gene contents led us to propose that the second copy of HP1105 and the JHP0562 may function as the GlcNAc and Gal transferase, respectively, to initiate synthesis of the Lewis antigen onto the Glc-Trio-Core in East-Asian strains lacking the HP1283/HP1578 genes. In view of the high gastric cancer rate in East Asia, the absence of the HP1283/HP1578 genes in East-Asian H. pylori strains warrants future studies addressing the role of the lipopolysaccharide heptan in pathogenesis.
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