Evidence map›Paper›PMID 31747297›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle.

Cynthia Koziol-White, Timothy B Johnstone, Maia L Corpuz, Gaoyuan Cao, Sarah Orfanos, Vishal Parikh, Brian Deeney, Omar Tliba, Rennolds S Ostrom, Ian Dainty and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. BetaFrontiers in medicine · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14.American journal of respiratory cell and molecular biology · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Why new biology must be uncovered to advance therapeutic strategies for chronic obstructive pulmonary disease.American journal of physiology. Lung cellular and molecular physiology · 2021
    Review
  16. Article
  17. Review
  18. Asthma without borders.American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
  19. Glucocorticoids rapidly activate cAMP production via GFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Cynthia Koziol-WhiteRutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey.
Timothy B JohnstoneDepartment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Maia L CorpuzDepartment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Gaoyuan CaoRutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey.
Sarah OrfanosRutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey.ORCID 0000-0002-8229-8562
Vishal ParikhRutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey.
Brian DeeneyRutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey.
Omar TlibaDepartment of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, New York.
Rennolds S OstromDepartment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Ian DaintyBioscience, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Reynold A PanettieriRutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey.
Rutgers, The State University of New Jersey · USChapman University · USAstraZeneca (Sweden) · SELong Island University · US

Funding

New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Airway Inflammatory Pathways Regulating Glucocorticoid Receptor PhosphorylationR01HL111541 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI TLIBA, OMAR · 2012 to 2021
$3.3M
Molecular signal transduction of cAMP compartmentsR01GM107094 · NIGMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI OSTROM, RENNOLDS S · 2015 to 2022
$2.3M
NCATS NIH HHS UL1 TR003017NHLBI NIH HHS R01 HL111541NIGMS NIH HHS R01 GM107094
6 · The paper itself

Abstract

The nongenomic mechanisms by which glucocorticoids modulate β

Indexed as

BronchiBronchodilator AgentsBudesonideCarbacholCell MembraneCholera ToxinColforsinCyclic AMPDinoprostoneFluticasoneFormoterol FumarateHumansMuscle, SmoothMyosin Light ChainsPhosphorylationPrednisoneBronchodilator AgentsBudesonideCarbacholCholera ToxinColforsinCyclic AMPDinoprostoneFluticasoneFormoterol Fumarateglucocorticoid receptor alphaMyosin Light ChainsPrednisoneReceptors, Glucocorticoidasthmabronchodilationchronic obstructive pulmonary diseasecorticosteroidssmooth muscle shortening

Identifiers

PMID31747297
PMCPMC7052668
OpenAlexW2990552960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.