Evidence map›Paper›PMID 31747114›Full record

ArticleChembiochem : a European journal of chemical biology2020

The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum tricornutum.

Lachlan Dow, Frederike Stock, Alexandra Peltekis, Dávid Szamosvári, Michaela Prothiwa, Adrien Lapointe, Thomas Böttcher, Benjamin Bailleul, Wim Vyverman, Peter G Kroth and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  5. Frontiers in microbiology · 2024
    Article
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Lachlan DowDepartment of Biology, University of Konstanz, Universitätsstrasse 10, 78467, Konstanz, Germany.ORCID 0000-0002-9994-9843
Frederike StockDepartment of Biology, Ghent University, Krijgslaan 281/S8, 9000, Ghent, Belgium.ORCID 0000-0001-8923-4273
Alexandra PeltekisInstitut de Biologie Physico-Chimique, CNRS-Sorbonne Université, 13 rue P. et M. Curie, 75005, Paris, France.
Dávid SzamosváriDepartment of Chemistry, University of Konstanz, Universitätsstrasse 10, 78467, Konstanz, Germany.
Michaela ProthiwaDepartment of Chemistry, University of Konstanz, Universitätsstrasse 10, 78467, Konstanz, Germany.
Adrien LapointeDepartment of Biology, University of Konstanz, Universitätsstrasse 10, 78467, Konstanz, Germany.
Thomas BöttcherDepartment of Chemistry, University of Konstanz, Universitätsstrasse 10, 78467, Konstanz, Germany.ORCID 0000-0003-0235-4825
Benjamin BailleulInstitut de Biologie Physico-Chimique, CNRS-Sorbonne Université, 13 rue P. et M. Curie, 75005, Paris, France.
Wim VyvermanDepartment of Biology, Ghent University, Krijgslaan 281/S8, 9000, Ghent, Belgium.ORCID 0000-0003-0850-2569
Peter G KrothDepartment of Biology, University of Konstanz, Universitätsstrasse 10, 78467, Konstanz, Germany.ORCID 0000-0003-4734-8955
Bernard LepetitDepartment of Biology, University of Konstanz, Universitätsstrasse 10, 78467, Konstanz, Germany.ORCID 0000-0001-9980-9210
University of Konstanz · DECentre National de la Recherche Scientifique · FRUniversity College Ghent · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms underlying interactions between diatoms and bacteria are crucial to understand diatom behaviour and proliferation, and can result in far-reaching ecological consequences. Recently, 2-alkyl-4-quinolones have been isolated from marine bacteria, both of which (the bacterium and isolated chemical) inhibited growth of microalgae, suggesting these compounds could mediate diatom-bacteria interactions. The effects of several quinolones on three diatom species have been investigated. The growth of all three was inhibited, with half-maximal inhibitory concentrations reaching the sub-micromolar range. By using multiple techniques, dual inhibition mechanisms were uncovered for 2-heptyl-4-quinolone (HHQ) in Phaeodactylum tricornutum. Firstly, photosynthetic electron transport was obstructed, primarily through inhibition of the cytochrome b

Indexed as

4-QuinolonesAdenosine TriphosphateChloroplastsCytochrome b6f ComplexDiatomsMitochondriaPhotosynthesisPlastidsThylakoids2-heptyl-4-quinolone4-QuinolonesAdenosine TriphosphateCytochrome b6f Complexcytochromesdiatom-bacteria interactionsphotosynthesisquinolonesreaction mechanisms

Identifiers

PMID31747114
PMCPMC7217009
OpenAlexW2991539425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.