ArticleNanoscale2020
Transverse lipid organization dictates bending fluctuations in model plasma membranes.
Article in Nanoscale, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranes.Communications chemistry · 2025Article
- Does vitamin E behave like cholesterol? An examination of vitamin E's effects on phospholipid membrane structure and dynamics through sum-frequency vibrational spectroscopy.Biophysical journal · 2025Article
- Evaluating Polarizable Biomembrane Simulations against Experiments.Journal of chemical theory and computation · 2024Article
- Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences.Cold Spring Harbor perspectives in biology · 2023Review
- The asymmetric plasma membrane-A composite material combining different functionalities?: Balancing Barrier Function and Fluidity for Effective Signaling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- Mitochondrial membrane model: Lipids, elastic properties, and the changing curvature of cardiolipin.Biophysical journal · 2023Article
- Distributing aminophospholipids asymmetrically across leaflets causes anomalous membrane stiffening.Biophysical journal · 2023Article
- Neutron scattering studies on dynamics of lipid membranes.Biophysics reviews · 2023Review
- A Guide to Your Desired Lipid-Asymmetric Vesicles.Membranes · 2023Review
- Small-Angle Neutron Scattering for Studying Lipid Bilayer Membranes.Biomolecules · 2022Review
- Cholesterol's balancing act: Defying the status quo.Biophysical journal · 2022Article
- Vesicle Viewer: Online visualization and analysis of small-angle scattering from lipid vesicles.Biophysical journal · 2021Article
- Article
- Stiffening Effect of the [Bmim][Cl] Ionic Liquid on the Bending Dynamics of DMPC Lipid Vesicles.The journal of physical chemistry. B · 2021Article
- Biomembrane Structure and Material Properties Studied With Neutron Scattering.Frontiers in chemistry · 2021Review
- Enhanced dynamics in the anomalous melting regime of DMPG lipid membranes.Structural dynamics (Melville, N.Y.) · 2020Article
- Dioctadecyldimethylammonium bromide, a surfactant model for the cell membrane: Importance of microscopic dynamics.Structural dynamics (Melville, N.Y.) · 2020Review
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Membrane undulations play a vital role in many biological processes, including the regulation of membrane protein activity. The asymmetric lipid composition of most biological membranes complicates theoretical description of these bending fluctuations, yet experimental data that would inform any such a theory is scarce. Here, we used neutron spin-echo (NSE) spectroscopy to measure the bending fluctuations of large unilamellar vesicles (LUV) having an asymmetric transbilayer distribution of high- and low-melting lipids. The asymmetric vesicles were prepared using cyclodextrin-mediated lipid exchange, and were composed of an outer leaflet enriched in egg sphingomyelin (ESM) and an inner leaflet enriched in 1-palmitoyl-2-oleoyl-phosphoethanolamine (POPE), which have main transition temperatures of 37 °C and 25 °C, respectively. The overall membrane bending rigidity was measured at three temperatures: 15 °C, where both lipids are in a gel state; 45 °C, where both lipids are in a fluid state; and 30 °C, where there is gel-fluid co-existence. Remarkably, the dynamics for the fluid asymmetric LUVs (aLUVs) at 30 °C and 45 °C do not follow trends predicted by their symmetric counterparts. At 30 °C, compositional asymmetry suppressed the bending fluctuations, with the asymmetric bilayer exhibiting a larger bending modulus than that of symmetric bilayers corresponding to either the outer or inner leaflet. We conclude that the compositional asymmetry and leaflet coupling influence the internal dissipation within the bilayer and result in membrane properties that cannot be directly predicted from corresponding symmetric bilayers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.