Evidence map›Paper›PMID 31746784›Full record

ArticlePhysics in medicine and biology2020

Arterial wall mechanical inhomogeneity detection and atherosclerotic plaque characterization using high frame rate pulse wave imaging in carotid artery disease patients in vivo.

Grigorios M Karageorgos, Iason Z Apostolakis, Pierre Nauleau, Vittorio Gatti, Rachel Weber, E Sander Connolly, Eliza C Miller, Elisa E Konofagou

Open access · greenAbstract read
In one paragraph

Article in Physics in medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Comparison of Filtering Methods for Calculating ARFI log(VoA) to Delineate Carotid Plaque Features, In Vivo.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Adaptive Wall Shear Stress Imaging in Phantoms, Simulations and In Vivo.IEEE transactions on bio-medical engineering · 2023
    Article
  6. Review
  7. Article
  8. Article
  9. Pulse Wave Imaging Coupled With Vector Flow Mapping: A Phantom, Simulation, and In Vivo Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Grigorios M KarageorgosDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Iason Z ApostolakisDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Pierre NauleauDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Vittorio GattiDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Rachel WeberDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
E Sander ConnollyDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, United States of America.
Eliza C MillerDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, United States of America.ORCID 0000-0002-7108-8906
Elisa E KonofagouDepartment of Biomedical Engineering, Columbia University, New York, NY, United States of America.
Columbia University · USColumbia University Irving Medical Center · USZero to Three · US

Funding

Carotid plaque assessment using Pulse Wave ImagingR01HL135734 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KONOFAGOU, ELISA E. · 2017 to 2020
$2.5M
Neurovascular Unit Dysfunction in Women with Severe PreeclampsiaK23NS107645 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, ELIZA C · 2019 to 2023
$1.1M
NHLBI NIH HHS R01 HL135734NINDS NIH HHS K23 NS107645
6 · The paper itself

Abstract

Pulse wave imaging (PWI) is a non-invasive, ultrasound-based technique, which provides information on arterial wall stiffness by estimating the pulse wave velocity (PWV) along an imaged arterial wall segment. The aims of the present study were to: (1) utilize the PWI information to automatically and optimally divide the artery into the segments with most homogeneous properties and (2) assess the feasibility of this method to provide arterial wall mechanical characterization in normal and atherosclerotic carotid arteries in vivo. A silicone phantom consisting of a soft and stiff segment along its longitudinal axis was scanned at the stiffness transition, and the PWV in each segment was estimated through static testing. The proposed algorithm detected the stiffness interface with an average error of 0.98  ±  0.49 mm and 1.04  ±  0.27 mm in the soft-to-stiff and stiff-to-soft pulse wave transmission direction, respectively. Mean PWVs estimated in the case of the soft-to-stiff pulse wave transmission direction were 2.47 [Formula: see text] 0.04 m s

Indexed as

Mechanical PhenomenaPulse Wave AnalysisAgedBiomechanical PhenomenaCarotid ArteriesCarotid Artery DiseasesFemaleHumansMaleMiddle AgedPhantoms, ImagingPlaque, AtheroscleroticUltrasonographyVascular Stiffness

Identifiers

PMID31746784
PMCPMC6980325
OpenAlexW2989646273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.