Evidence map›Paper›PMID 31746740›Full record

ArticleeLife2019

Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices.

Claudia Racioppi, Keira A Wiechecki, Lionel Christiaen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Regulation of motor neuron differentiation in thebioRxiv : the preprint server for biology · 2025
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  8. Characterization ofNAR genomics and bioinformatics · 2024
    Article
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  16. Review
  17. Brain Sensory Organs of the AscidianFrontiers in cell and developmental biology · 2021
    Review
  18. Review
  19. Review
  20. Functional genomic approaches to elucidate the role of enhancers during development.Wiley interdisciplinary reviews. Systems biology and medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Claudia RacioppiCenter for Developmental Genetics, Department of Biology, New York University, New York, United States.ORCID 0000-0001-8117-1124
Keira A WiecheckiCenter for Developmental Genetics, Department of Biology, New York University, New York, United States.ORCID 0000-0003-0572-6284
Lionel ChristiaenCenter for Developmental Genetics, Department of Biology, New York University, New York, United States.ORCID 0000-0001-5930-5667
New York University · US

Funding

Regulation of muscle fate specification and cell migration in cardiogenic lineageR01HL108643 · NHLBI · NEW YORK UNIVERSITY · PI MOGILNER, ALEXANDER · 2011 to 2023
$5.4M
Modeling Gene Regulatory Networks for Early Cardiopharyngeal DevelopmentR01HD096770 · NICHD · NEW YORK UNIVERSITY · PI BONNEAU, RICHARD A, CHRISTIAEN, LIONEL · 2018 to 2022
$3.0M
European Molecular Biology Organization Long Term FellowshipFondation Leducq 15CVD01Leducq Foundation 15CVD01NHLBI NIH HHS R01 HL108643NICHD NIH HHS R01 HD096770
6 · The paper itself

Abstract

During embryogenesis, chromatin accessibility profiles control lineage-specific gene expression by modulating transcription, thus impacting multipotent progenitor states and subsequent fate choices. Subsets of cardiac and pharyngeal/head muscles share a common origin in the cardiopharyngeal mesoderm, but the chromatin landscapes that govern multipotent progenitors competence and early fate choices remain largely elusive. Here, we leveraged the simplicity of the chordate model

Indexed as

AnimalsCell DifferentiationChromatinCiona intestinalisEmbryonic DevelopmentEmbryo, NonmammalianForkhead Transcription FactorsGene Expression Regulation, DevelopmentalHeartMesodermPharyngeal MusclesPharynxT-Box Domain ProteinsTrans-ActivatorsChromatinForkhead Transcription FactorsT-Box Domain ProteinsTrans-ActivatorsATAC-seqchordateC. intestinalisCRISPR/Cas9developmental biologyenhancergeneticsgenomicsheartPharyngeal muscle

Identifiers

PMID31746740
PMCPMC6952182
OpenAlexW2990257616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.