ArticleProceedings of the National Academy of Sciences of the United States of America1988
Prolonged RNA changes in the Hermissenda eye induced by classical conditioning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Binding of Gd(3+) to the neuronal signalling protein calexcitin identifies an exchangeable Ca(2+)-binding site.Acta crystallographica. Section F, Structural biology communications · 2016Article
- Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Reconstruction of ionic currents in a molluscan photoreceptor.Biophysical journal · 1993Article
- GTP-binding proteins and potassium channels involved in synaptic plasticity and learning.Molecular neurobiology · 1991Review
- Contraction of neuronal branching volume: an anatomic correlate of Pavlovian conditioning.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Specific high molecular weight mRNAs induced by associative learning in Hermissenda.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Possible molecular-cellular mechanisms of the regulation of gene expression during learning.Neuroscience and behavioral physiologyReview
- Conditioned defensive reflex in the edible snail (molecular-genetic aspects).Neuroscience and behavioral physiologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incorporation of 32P into mRNA and the total amount of mRNA were increased 3- to 4-fold in eyes isolated from Hermissenda crassicornis trained to associate light with rotation on a turntable compared with animals trained with equal numbers of light and rotation events presented randomly and with naive animals. Incorporation of 32P into poly(A)- RNA was reduced by as much as 60%. The RNA changes were strongly correlated with the degree of learning and could not be accounted for by changes in [32P]ATP content. The RNA changes were maximal at 24 hr and were still detectable after 4 days, indicating that associative conditioning produces a period of increased DNA transcription that could be an intermediate step in memory consolidation. The RNA changes may in part account for recently observed conditioning-specific changes in the synthesis rates of specific proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.