ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020
Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting.Annals of medicine · 2026Review
- Parasympathetic Airway Hyperreactivity Is Enhanced in Acute but Not Chronic Eosinophilic Asthma Mouse Models.American journal of respiratory cell and molecular biology · 2025Article
- Location, Location, Location: Unpacking Eosinophils' Roles in Obesity-related Asthma.American journal of respiratory and critical care medicine · 2025Article
- Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Vagal Reflexes in Airway Hyperreactivity: Novel Pathways and a Note of Caution for Studies in Mice.American journal of respiratory cell and molecular biology · 2023Article
- Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice.JCI insight · 2022Article
- Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.JACC. Basic to translational science · 2022Review
- Airway smooth muscle function in asthma.Frontiers in physiology · 2022Review
- Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma.Frontiers in immunology · 2022Review
- Asthma without borders.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Fetal Eosinophils Get on the Nerves of Airways. Early Origins of Bronchoconstriction.American journal of respiratory cell and molecular biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Eosinophils mediate airway hyperresponsiveness by increasing vagally mediated reflex bronchoconstriction. Here, we tested whether circulating or airway eosinophils change nerve function. Airway resistance in response to aerosolized 5-hydroxytryptamine (5-HT, 10-300 mM) was measured in wild-type mice or transgenic mice that overexpress IL5 in T cells (+IL5
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.