Evidence map›Paper›PMID 31746604›Full record

ArticleThe Journal of organic chemistry2020

Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin.

Hyunjun Yang, Arthur V Pishenko, Xingyue Li, James S Nowick

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Drug repurposing of natural depsipeptide fromFrontiers in pharmacology · 2025
    Article
  3. Article
  4. Article
  5. Investigation of Isobactin Analogues of Teixobactin.ACS medicinal chemistry letters · 2024
    Article
  6. Article
  7. New Teixobactin Analogues with a Total Lactam Ring.ACS medicinal chemistry letters · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hyunjun YangDepartment of Chemistry and Department of Pharmaceutical Sciences , University of California , Irvine , California 92697-2025 , United States.ORCID 0000-0003-2524-2201
Arthur V PishenkoDepartment of Chemistry and Department of Pharmaceutical Sciences , University of California , Irvine , California 92697-2025 , United States.
Xingyue LiDepartment of Chemistry and Department of Pharmaceutical Sciences , University of California , Irvine , California 92697-2025 , United States.
James S NowickDepartment of Chemistry and Department of Pharmaceutical Sciences , University of California , Irvine , California 92697-2025 , United States.ORCID 0000-0002-2273-1029

Funding

Development of Teixobactin AnaloguesR56AI137258 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2018 to 2018
$444k
Synthesis and Studies of a New Family of AntibioticsR21AI121548 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2016 to 2017
$372k
Howard Hughes Medical InstituteNIAID NIH HHS R21 AI121548NIAID NIH HHS R56 AI137258
6 · The paper itself

Abstract

This paper describes the chemical synthesis, X-ray crystallographic structure, and antibiotic activity assay of lactam analogues of teixobactin and explores ring-expanded analogues of teixobactin with β

Indexed as

DepsipeptidesLactamsAnti-Bacterial AgentsMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsDepsipeptidesLactamsteixobactin

Identifiers

PMID31746604
PMCPMC7814697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.