ArticleMolecular medicine reports2020
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Cholesterol-Lowering Treatment Blocks Epithelial-Mesenchymal Transition (EMT) Associated Invasiveness and Drug Resistance in Breast and Colorectal Adenocarcinoma Models.Cancer medicine · 2026Article
- The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches.Medicinal research reviews · 2026Review
- Enhancing the Water Solubility and Efficacy of Anticancer Drugs Using Hydroxypropyl-β-Cyclodextrin.International journal of molecular sciences · 2026Review
- 2-Hydroxypropyl-β-cyclodextrin (HPβCD) as a Potential Therapeutic Agent for Breast Cancer.Cancers · 2023Article
- Advanced DNA Zipper Probes for Detecting Cell Membrane Lipid Domains.Nano letters · 2022Article
- Collagen Remodeling along Cancer Progression Providing a Novel Opportunity for Cancer Diagnosis and Treatment.International journal of molecular sciences · 2022Review
- Role of theFrontiers in cell and developmental biology · 2022Review
- JI017, a Complex Herbal Medication, Induces Apoptosis via the Nox4-PERK-CHOP Axis in Ovarian Cancer Cells.International journal of molecular sciences · 2021Article
- Article
- Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer.International journal of molecular sciences · 2021Review
- Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer.Frontiers in cell and developmental biology · 2021Review
- Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives.Cancers · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epithelial‑to‑mesenchymal transition (EMT) has been reported to serve vital roles in regulating the progress of cancer metastasis. In addition, lipid rafts enriched in sphingolipids and cholesterol serve important roles in physiological and biochemical processes as a signaling platform. The present study explored the effects of hydroxypropyl‑β‑cyclodextrin (HP‑β‑CD), a cholesterol‑depleting agent of lipid rafts, on the transforming growth factor (TGF)‑β/Smad signaling pathway and endoplasmic reticulum (ER) stress in mediating EMT in MDA‑MB‑231 breast cancer cells. HP‑β‑CD treatment inhibited TGF‑β1‑induced EMT, based on increased expression of E‑cadherin and decreased expression of vimentin. HP‑β‑CD reduced the expression of the TGF receptor TβRI and blocked the phosphorylation of Smad2. In addition, HP‑β‑CD increased the expression of ER stress‑related proteins (binding immunoglobulin protein and activating transcription factor 6), but TGF‑β1 could reverse these changes. Sodium 4‑phenylbutyrate, an inhibitor of ER stress, suppressed these effects of HP‑β‑CD on EMT and TGF‑β/Smad signaling pathway inhibition in breast cancer cells. Thus, HP‑β‑CD can block the TGF‑β/Smad signaling pathway via diminishing the expression of TβRI which helps to activate ER stress and attenuate EMT in MDA‑MB‑231 cells, highlighting a potential target of lipid rafts for breast cancer treatment.
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