ReviewJournal of toxicology and environmental health. Part B, Critical reviews2020
Genetic toxicity assessment using liver cell models: past, present, and future.
Review in Journal of toxicology and environmental health. Part B, Critical reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials.Life sciences · 2020Pooled it
- Sea Urchin-Like Platinum-Coated Gold Nanozymes-Based Ultra-Sensitive Colorimetric Detection and Mechanism Differentiation Platform for Dual-Marker Guided Genotoxicity Assessment.Advanced healthcare materials · 2026Article
- Human 3D liver spheroids support productive infection of a novel tick-borne phenuivirus.One health (Amsterdam, Netherlands) · 2026Article
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids.NAM journal · 2026Article
- Rediscovering Diazaborines: Synthesis and Bioactivity Profiling of Boron-Containing FabI Inhibitors against Gram-Negative Bacteria.Journal of medicinal chemistry · 2026Article
- A simple suspension culture method for generating human iPSC-derived liver organoids.Biology methods & protocols · 2026Article
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing.Toxicology in vitro : an international journal published in association with BIBRA · 2025Article
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes.Chemico-biological interactions · 2025Article
- Almond-like Aroma Formation of Acid Whey byJournal of agricultural and food chemistry · 2025Article
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2025Article
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models.Archives of toxicology · 2023Article
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing.Archives of toxicology · 2023Article
- Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi.Archives of toxicology · 2022Review
- Comparative Analysis of Transcriptional Responses to Genotoxic and Non-Genotoxic Agents in the Blood Cell Model TK6 and the Liver Model HepaRG.International journal of molecular sciences · 2022Article
- Cell Chirality as a Novel Measure for Cytotoxicity.Advanced biology · 2022Review
- The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2022Article
- DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies.Archives of toxicology · 2022Article
- In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling.Cancers · 2021Review
- Connexin-Based Channel Activity Is Not Specifically Altered by Hepatocarcinogenic Chemicals.International journal of molecular sciences · 2021Article
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta).Toxicology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Genotoxic compounds may be detoxified to non-genotoxic metabolites while many pro-carcinogens require metabolic activation to exert their genotoxicity
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.