Evidence map›Paper›PMID 31746195›Full record

ArticleACS infectious diseases2020

Calcium Ions Directly Interact with the Ebola Virus Fusion Peptide To Promote Structure-Function Changes That Enhance Infection.

Lakshmi Nathan, Alex L Lai, Jean Kaoru Millet, Marco R Straus, Jack H Freed, Gary R Whittaker, Susan Daniel

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  4. The Journal of general virology · 2025
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  14. A novelMicrobiology spectrum · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lakshmi NathanRobert Frederick Smith School of Chemical and Biomolecular Engineering , Cornell University , 120 Olin Hall, Ithaca , New York 14853 , United States.
Alex L LaiBaker Laboratory, Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.
Jean Kaoru MilletDepartment of Microbiology and Immunology, College of Veterinary Medicine , Cornell University , Ithaca , New York 14853 , United States.ORCID 0000-0001-8373-3688
Marco R StrausDepartment of Microbiology and Immunology, College of Veterinary Medicine , Cornell University , Ithaca , New York 14853 , United States.
Jack H FreedBaker Laboratory, Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.ORCID 0000-0003-4288-2585
Gary R WhittakerDepartment of Microbiology and Immunology, College of Veterinary Medicine , Cornell University , Ithaca , New York 14853 , United States.
Susan DanielRobert Frederick Smith School of Chemical and Biomolecular Engineering , Cornell University , 120 Olin Hall, Ithaca , New York 14853 , United States.ORCID 0000-0001-7773-0835
Cornell University · US

Funding

TR&D 4 for ACERT, 2017-2021 funding periodP41GM103521 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2012 to 2021
$11.7M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Electron Spin Relaxation in Model MembranesR01GM123779 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2017 to 2020
$2.1M
X/Q Band Pulsed ENDOR SpectrometerS10OD021543 · OD · CORNELL UNIVERSITY · PI FREED, JACK H · 2016 to 2016
$1.4M
NIGMS NIH HHS P41 GM103311NIGMS NIH HHS P41 GM103521NIGMS NIH HHS R01 GM123779NIH HHS S10 OD021543
6 · The paper itself

Abstract

Ebola virus disease is a serious global health concern given its periodic occurrence, high lethality, and the lack of approved therapeutics. Certain drugs that alter intracellular calcium, particularly in endolysosomes, have been shown to inhibit Ebola virus infection; however, the underlying mechanism is unknown. Here, we provide evidence that

Indexed as

Virus InternalizationAnimalsCalciumChlorocebus aethiopsEbolavirusHemorrhagic Fever, EbolaIonsProtein ConformationStructure-Activity RelationshipVero CellsViral Fusion ProteinsCalciumIonsViral Fusion ProteinscalciumEbolafusion peptidevirus entry

Identifiers

PMID31746195
PMCPMC7040957
OpenAlexW2990108599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.