ArticleJournal of biomedical optics2019
Co-registered photoacoustic and ultrasound imaging of human colorectal cancer.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Development of a Dual Photoacoustic-Ultrasound Imaging System: Current Status and Future Perspectives.Sensors (Basel, Switzerland) · 2026Review
- Photoacoustic-Integrated Multimodal Approach for Colorectal Cancer Diagnosis.ACS biomaterials science & engineering · 2025Review
- Dual-modality ultrasound/photoacoustic tomography for mapping tissue oxygen saturation distribution in intestinal strangulation.Photoacoustics · 2025Article
- Advances in photoacoustic imaging aided by nano contrast agents: special focus on role of lymphatic system imaging for cancer theranostics.Journal of nanobiotechnology · 2023Review
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
- Size and depth of residual tumor after neoadjuvant chemoradiotherapy in rectal cancer - implications for the development of new imaging modalities for response assessment.Frontiers in oncology · 2023Article
- Ultrasound-enhanced Unet model for quantitative photoacoustic tomography of ovarian lesions.Photoacoustics · 2022Article
- The emerging role of photoacoustic imaging in clinical oncology.Nature reviews. Clinical oncology · 2022Review
- Clinical photoacoustic/ultrasound dual-modal imaging: Current status and future trends.Frontiers in physiology · 2022Review
- Photoacoustic tomography reconstruction using lag-based delay multiply and sum with a coherence factor improves in vivo ovarian cancer diagnosis.Biomedical optics express · 2021Article
- Role of blood oxygenation saturation in ovarian cancer diagnosis using multi-spectral photoacoustic tomography.Journal of biophotonics · 2021Article
- Clear cell renal cell carcinoma detection by multimodal photoacoustic tomography.Photoacoustics · 2021Article
- Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment.Photoacoustics · 2020Article
- Repurposing Molecular Imaging and Sensing for Cancer Image-Guided Surgery.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Review
- Adaptive Boosting (AdaBoost)-based multiwavelength spatial frequency domain imaging and characterization for ex vivo human colorectal tissue assessment.Journal of biophotonics · 2020Article
- Fiber endface illumination diffuser for endo-cavity photoacoustic imaging.Optics letters · 2020Article
- Recent research progress of photoacoustic endoscopy in the digestive system.Endoscopic ultrasoundArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
<p>Colorectal cancer is the second most common malignancy diagnosed globally. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. Although prior studies have demonstrated the capability of photoacoustic imaging techniques to differentiate normal from neoplastic tissue in the gastrointestinal tract, evaluation of deep tissue with a fast speed and a large field of view remains limited. To investigate the ability of photoacoustic technology to image deeper tissue, we conducted a pilot study using a real-time co-registered photoacoustic tomography (PAT) and ultrasound (US) system. A total of 23 <italic>ex vivo</italic> human colorectal tissue samples were imaged immediately after surgical resection. Co-registered photoacoustic images of malignancies showed significantly increased PAT signal compared to normal regions of the same sample. The quantitative relative total hemoglobin (rHbT) concentration computed from four optical wavelengths, the spectral features, such as the mean spectral slope, and 0.5-MHz intercept extracted from PAT and US spectral data, and image features, such as the first- and second-order statistics along with the standard deviation of the mean radon transform of PAT images, have shown statistical significance between untreated colorectal tumors and the normal tissue. Using either a logistic regression model or a support vector machine, the best set of parameters of rHbT and PAT intercept has achieved area-under-the-curve (AUC) values of 0.97 and 0.95 for both training and testing data sets, respectively, for prediction of histologically confirmed invasive carcinoma.</p>.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.