ArticleMicrobiologyOpen2020
Evolutionary changes of an intestinal Lactobacillus reuteri during probiotic manufacture.
Article in MicrobiologyOpen, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- A plasmid with theMicrobiology (Reading, England) · 2025Article
- Salmonella grows massively and aerobically in chicken faecal matter.Microbial biotechnology · 2020Article
- Evolutionary changes of an intestinal Lactobacillus reuteri during probiotic manufacture.MicrobiologyOpen · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probiotic bacteria are frequently used to treat intestinal diseases or to improve health; however, little is known about the evolutionary changes of these bacteria during probiotic manufacture and the bacterial ability to colonize the intestine. It has been observed that when bacteria adapt to a new environment, they lose some traits required to thrive in the original niche. In this study, a strain of Lactobacillus reuteri was isolated from mouse duodenum and subjected to 150 serial passes in milk to simulate the industrial propagation of probiotic bacteria. The strains adapted to milk outperformed their ancestor when grown in milk; we also showed evidence of reduced intestinal colonization of milk-adapted strains. Whole-genome sequencing showed that bacterial adaptation to milk selects mutants with altered metabolic functions.
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Registered trials
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