Evidence map›Paper›PMID 31746083›Full record

ArticleHuman brain mapping2020

Parcellation influence on the connectivity-based structure-function relationship in the human brain.

Arnaud Messé

Abstract read
In one paragraph

Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A co-alteration parceling of the cingulate cortex.Brain structure & function · 2022
    Pooled it
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  4. The progression of sex differences in brain networks across the lifespan.bioRxiv : the preprint server for biology · 2026
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Arnaud MesséDepartment of Computational Neuroscience, University Medical Center Eppendorf, Hamburg University, Hamburg, Germany.ORCID 0000-0001-9081-3088

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

One of the fundamental questions in neuroscience is how brain structure and function are intertwined. MRI-based studies have demonstrated a close relationship between the physical wiring of the brain (structural connectivity) and the associated patterns of synchronization (functional connectivity). However, little is known about the spatial consistency of such a relationship and notably its potential dependence on brain parcellations. In the present study, we performed a comparison of a set of state-of-the-art group-wise brain atlases, with various spatial resolutions, to relate structural and functional connectivity derived from high quality MRI data. We aim to investigate if the definition of brain areas influences the relationship between structural and functional connectivity. We observed that there is a significant effect of brain parcellations, which is mainly driven by the number of areas; there are mixed differences in the SC-FC relationship when compared to purely random parcellations; the influence of the number of areas cannot be attributed solely to the reliability of the connectivity estimates; and beyond the influence of the number of regions, the spatial embedding of the brain (distance effect) can explain a large portion of the observed relationship. As such the choice of a brain parcellation for connectivity analyses remains most likely a matter of convenience.

Indexed as

Atlases as TopicBrainConnectomeGray MatterHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeural PathwaysReproducibility of ResultsWhite Matterbrain connectivityparcellationstructure-function relationship

Identifiers

PMID31746083
PMCPMC7267927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.