Evidence map›Paper›PMID 31745972›Full record

ArticleInternational journal of cancer2020

The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies.

Jieun Jang, Tianyi Wang, Hui Cai, Fei Ye, Gwen Murphy, Taichi Shimazu, Philip R Taylor, You-Lin Qiao, Keun-Young Yoo, Sun Ha Jee and 9 more

Abstract readMulticenter Study
In one paragraph

Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease-gene network.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. The role of SWI/SNF complexes in digestive system neoplasms.Medical oncology (Northwood, London, England) · 2024
    Review
  6. Article
  7. Article
  8. Ethnic-specific associations between body mass index and gastric cancer: a Mendelian randomization study in European and Korean populations.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jieun JangDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Tianyi WangDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Hui CaiDivision of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Nashville, TN.
Fei YeDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Gwen MurphyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.ORCID 0000-0003-0118-5337
Taichi ShimazuEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Philip R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
You-Lin QiaoDepartment of Cancer Epidemiology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Keun-Young YooDepartment of Biomedical Science, Seoul National University Graduate School, Seoul, Republic of Korea.
Sun Ha JeeDepartment of Epidemiology and Health Promotion, Institute for Health Promotion, Yonsei University, Seoul, South Korea.
Jeongseon KimDivision of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Goyang, South Korea.ORCID 0000-0002-0889-2686
Sheau-Chiann ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Wei ZhengDivision of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Nashville, TN.ORCID 0000-0003-1226-070X
Xiao-Ou ShuDivision of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Nashville, TN.ORCID 0000-0002-0711-8314
Michael PawlitaDivision of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DFKZ), Heidelberg, Germany.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-5002-9707
Meira EppleinCancer Control and Population Sciences Program, Duke Cancer Institute, Durham, NC.ORCID 0000-0001-5646-6430

Funding

Nutrition Intervention Trials in Linxian ChinaZIACP000112 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$8.2M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
Helicobacter pylori blood biomarker for gastric cancer risk in East AsiaR01CA174853 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EPPLEIN, MEIRA · 2013 to 2016
$2.3M
NCI NIH HHS R01 CA174853NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910
6 · The paper itself

Abstract

The association between body mass index (BMI) and noncardia gastric cancer (NCGC) risk remains controversial. The purpose of our study was to examine the association of BMI with NCGC risk with consideration of Helicobacter pylori (HP) biomarkers. This international nested case-control study, composed of 1,591 incident NCGC cases and 1,953 matched controls, was established from eight cohorts in China, Japan and Korea, where the majority of NCGCs are diagnosed worldwide. HP antibody biomarkers were measured in blood collected at cohort enrollment by multiplex serology. The NCGC risk according to baseline BMI was estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CIs). We found a U-shaped association between BMI category and NCGC risk. Compared to those with reference BMI (22.6-25.0 kg/m

Indexed as

AgedAntibodies, BacterialBody Mass IndexCase-Control StudiesChinaFemaleHelicobacter InfectionsHelicobacter pyloriHumansJapanLogistic ModelsMaleMiddle AgedProspective StudiesRepublic of KoreaRisk FactorsAntibodies, Bacterialbiomarkersbody mass indexHelicobacter pylorinoncardia gastric cancerstomach neoplasms

Identifiers

PMID31745972
PMCPMC7234914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.