ArticleEuropean journal of epidemiology2020
Pregnancy, pregnancy loss and the risk of diabetes in Chinese women: findings from the China Kadoorie Biobank.
Article in European journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Fetal loss and long-term maternal morbidity and mortality: A systematic review and meta-analysis.PLoS medicine · 2024Pooled it
- Trial
- Association between adverse obstetric history and perinatal outcomes in singleton and twin pregnancies: a retrospective study.Frontiers in medicine · 2026Article
- Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women.BMC women's health · 2025Article
- Stillbirth increase long-term health risks of diabetes, CVD, CVD mortality, and all-cause mortality.BMC women's health · 2025Article
- Association of Female Reproductive Factors with Incident Cardiometabolic Disease: Finding from a European Population-Based Study.Global heart · 2025Article
- Differential mRNA and lncRNA Expression Profiles Associated with Early Pregnancy Loss in ART Patients.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Pregnancy loss and risk of cardiometabolic multimorbidity in Chinese women: the China Kadoorie Biobank study.BMC public health · 2024Article
- Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis.EClinicalMedicine · 2024Review
- Incident Diabetes in Women With Patterns of Gestational Diabetes Occurrences Across 2 Pregnancies.JAMA network open · 2024Article
- Expression and clinical significance of miR-141-5p as a biomarker in the serum of patients with early spontaneous abortion.Clinics (Sao Paulo, Brazil) · 2024Article
- Article
- A roadmap for sex- and gender-disaggregated health research.BMC medicine · 2023Article
- The mediating role of inflammation in the association between pregnancy loss history and gestational diabetes mellitus.Diabetology & metabolic syndrome · 2023Article
- Pregnancy complications and later life women's health.Acta obstetricia et gynecologica Scandinavica · 2023Review
- Pregnancy Loss and Risk of All-Cause Mortality in Chinese Women: Findings From the China Kadoorie Biobank.International journal of public health · 2023Article
- Association between the vaginal and uterine microbiota and the risk of early embryonic arrest.Frontiers in microbiology · 2023Article
- Diabetic and Hypertensive Disorders Following Miscarriage: A Protocol for Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Article
- Association of History of Spontaneous or Induced Abortion With Subsequent Risk of Gestational Diabetes.JAMA network open · 2022Article
- Independent value of serumFrontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
Pregnancy and pregnancy loss may be associated with increased risk of diabetes in later life. However, the evidence is inconsistent and sparse, especially among East Asians where reproductive patterns differ importantly from those in the West. We examined the associations of pregnancy and pregnancy loss (miscarriage, induced abortion, and still birth) with the risk of incident diabetes in later life among Chinese women. In 2004-2008, the nationwide China Kadoorie Biobank recruited 302 669 women aged 30-79 years from 10 (5 urban, 5 rural) diverse localities. During 9.2 years of follow-up, 7780 incident cases of diabetes were recorded among 273,383 women without prior diabetes and cardiovascular disease at baseline. Cox regression yielded multiple-adjusted hazard ratios (HRs) for the risk of diabetes associated with pregnancy and pregnancy loss. Overall, 99% of women had been pregnant, of whom 10%, 53%, and 6% reported having a history of miscarriage, induced abortion, and stillbirth, respectively. Among ever pregnant women, each additional pregnancy was associated with an adjusted HR of 1.04 (95% CI 1.03; 1.06) for diabetes. Compared with those without pregnancy loss, women with a history of pregnancy loss had an adjusted HR of 1.07 (1.02; 1.13) and the HRs increased with increasing number of pregnancy losses, irrespective of the number of livebirths; the adjusted HR was 1.03 (1.00; 1.05) for each additional pregnancy loss. The strength of the relationships differed marginally by type of pregnancy loss. Among Chinese women, a higher number of pregnancies and pregnancy losses were associated with a greater risk of diabetes.
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