ArticleEnvironmental science and pollution research international2019
The anti-inflammatory influence of Cinnamomum burmannii against multi-walled carbon nanotube-induced liver injury in rats.
Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Carbon nanoparticle toxicity assessment in the liver of male Sprague-Dawley rats.Open veterinary journal · 2025Article
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- Molecular mechanism of nanomaterials induced liver injury: A review.World journal of hepatology · 2024Review
- The effects of TiO2, ZnO, IONs and Al2O3 metallic nanoparticles on theToxicology research · 2024Article
- Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders.Antioxidants (Basel, Switzerland) · 2024Review
- Oxidative Stress in Long-Term Exposure to Multi-Walled Carbon Nanotubes in Male Rats.Antioxidants (Basel, Switzerland) · 2023Article
- Amelioration of aluminum-induced hepatic and nephrotoxicity by Premna odorata extract is mediated by lowering MMP9 and TGF-β gene alterations in Wistar rat.Environmental science and pollution research international · 2022Article
- Hepatoprotection ofVeterinary world · 2022Article
- Premna odorata extract as a protective agent on neurotoxic effect of aluminum: neurochemical, molecular, and histopathological alterations.Environmental science and pollution research international · 2021Article
- Nanoparticles: A Hope for the Treatment of Inflammation in CNS.Frontiers in pharmacology · 2021Review
- The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens.Bioscience reports · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon nanotubes (CNTs) are extensively used in nanotechnology due to their unique physico-chemical properties. CNTs were implicated in many disorders connected with human health. So, we aimed in this study to provide new insight into the role of aqueous C. burmannii in treating the possible hepatotoxic effects of multi-walled carbon nanotube (MWCNTs) exposure. A total of 32 male albino rats were divided into 4 groups: control group, cinnamon-treated group, MWCNT-treated, and cinnamon- and MWCNT-treated group. To achieve the aim of this study, evaluation of percentage change of body weight, oxidant, and antioxidant status including lipid peroxidation (LPO), nitrite, total thiols, glutathione contents (GSH), the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S transferase (GST) was done. Histopathological examination and the rate of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-1 (COX-1), and tumor necrotic factor-α were performed. Oral administration of aqueous C. burmannii to those MWCNT-treated rats resulted in a significant reduction in LPO and total thiol contents with a significant elevation in the activities of SOD, CAT, and GPX, while GSH content and GST activity were not significantly affected. We observed a significant downregulation in the rate of previous pro-inflammatory cytokines. All this improvement in these examined markers resulted in a significant modulation in the hepatic histopathological lesions caused by MWCNTs. Aqueous C. burmannii extract exhibited a potential defensive effect on the hepatic injury triggered by MWCNTs through upgrading the antioxidant system and downregulating the rate of pro-inflammatory cytokines.
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