ArticleJournal of assisted reproduction and genetics2020
Transcriptome sequencing of endometrium revealed alterations in mRNAs and lncRNAs after ovarian stimulation.
Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Trial
- Review
- Comprehensive transcriptomic profiling of dynamic endometrial alterations during different implantation stages in goats (Capra hircus).Journal of animal science · 2025Article
- The impact of ovarian stimulation on the human endometrial microenvironment.Human reproduction (Oxford, England) · 2024Article
- A systematic review of transcriptomic studies of the human endometrium reveals inconsistently reported differentially expressed genes.Reproduction & fertility · 2023Article
- Small Non-Coding RNAs as New Biomarkers to Evaluate the Quality of the Embryo in the IVF Process.Biomolecules · 2022Article
- The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism.RNA biology · 2021Review
- The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium.Clinical epigenetics · 2021Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
research questionUsing RNA-sequencing analysis, we investigated the relationship between ovarian stimulation and endometrial transcriptome profiles during the window of implantation (WOI) to identify candidate predictive factors for the WOI and to optimize timing for embryo transfer.
methodsTwelve women with normal basal hormone levels and regular ovulation were randomly assigned into three groups based on sampling time: late-proliferate phase (P group), and receptive phase in natural cycles (LH+7, N group) and stimulated cycles (hCG+7, S group). Transcriptome profiles of mRNAs and long non-coding RNAs (lncRNAs) were then compared among the three groups. Validation was performed using real-time qPCR.
resultsComparison of transcriptome profiles between the natural and stimulated endometrium revealed 173 differentially expressed genes (DEGs), with a > 2-fold change (FC) and p < 0.05, under the influence of supraphysiological estradiol (E
conclusionUsing mRNA and lncRNA sequencing, we found that supraphysiological E REGISTRATION NUMBER: ChiCTR180001453.
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