Evidence map›Paper›PMID 31745723›Full record

Observational studyJournal of neurology2020

Diagnostic accuracy of MRI parameters in pure akinesia with gait freezing.

Keiichi Nakahara, Shunya Nakane, Mika Kitajima, Tomoko Masuda-Narita, Hidenori Matsuo, Yukio Ando

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Magnetic Susceptibility in Progressive Supranuclear Palsy Variants, Parkinson's Disease, and Corticobasal Syndrome.Movement disorders : official journal of the Movement Disorder Society · 2023
    Article
  2. Article
  3. Review
  4. Brainstem Biomarkers of Clinical Variant and Pathology in Progressive Supranuclear Palsy.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keiichi NakaharaDepartment of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Shunya NakaneDepartment of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. nakaneshunya@gmail.com.ORCID http://orcid.org/0000-0003-1958-095X
Mika KitajimaDepartment of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Tomoko Masuda-NaritaDepartment of Neurology, National Hospital Organization Nagasaki Kawatana Medical Center, 2005-1 Shimogumigo, Kawatana-cho, Higashisonogi-gun, Nagasaki, 859-3615, Japan.
Hidenori MatsuoDepartment of Neurology, National Hospital Organization Nagasaki Kawatana Medical Center, 2005-1 Shimogumigo, Kawatana-cho, Higashisonogi-gun, Nagasaki, 859-3615, Japan.
Yukio AndoDepartment of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the usefulness of MRI measurements in patients with pure akinesia with gait freezing (PAGF), Richardson's syndrome, and Parkinson's disease for diagnosis.

methodsWe obtained MRI measurements for patients with PAGF, Richardson's syndrome, or Parkinson's disease: 9 patients with PAGF, 26 with Richardson's syndrome, and 93 with Parkinson's disease. We measured the area of the pons and midbrain on midsagittal MRIs and the midbrain width on axial MRIs. We also calculated the mean values of the superior cerebellar peduncle, middle cerebellar peduncle, and cerebral crus width; the pons area-to-midbrain area ratio; the middle cerebellar peduncle width-to-superior cerebellar peduncle width ratio; and the magnetic resonance (MR) Parkinsonism index.

resultsThe Richardson's syndrome group had the highest pons area-to-midbrain area ratio and MR Parkinsonism index; the Parkinson's disease group had the lowest values. The Parkinson's disease group also had the highest midbrain width and cerebral crus width, with the lowest values being seen in the Richardson's syndrome group. The PAGF group had the intermediate values of the pons area-to-midbrain area ratio and MR Parkinsonism index between the Richardson's syndrome group and the Parkinson's disease group, whereas significant differences were found only in the pons area-to-midbrain area ratio. Results from receiver operating characteristic curve analyses showed that the pons area-to-midbrain area ratio has a higher sensitivity, specificity, and accuracy than the MR Parkinsonism index.

conclusionsThe pons area-to-midbrain area ratio is more useful to distinguish PAGF from Richardson's syndrome and Parkinson's disease than the MR Parkinsonism index.

Indexed as

AgedAged, 80 and overBrainFemaleGait Disorders, NeurologicHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingParkinson DiseaseSupranuclear Palsy, ProgressiveMR parkinsonism indexParkinson’s diseaseP/MBProgressive supranuclear palsyPure akinesia with gait freezingRichardson’s syndrome

Identifiers

PMID31745723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.