Evidence map›Paper›PMID 31745569›Full record

ReviewCurrent genetics2020

Sky1: at the intersection of prion-like proteins and stress granule regulation.

Jenifer E Shattuck, Sean M Cascarina, Kacy R Paul, Eric D Ross

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jenifer E ShattuckDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Sean M CascarinaDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Kacy R PaulDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Eric D RossDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA. Eric.Ross@colostate.edu.ORCID http://orcid.org/0000-0002-6473-9977

Funding

Functional and Pathological Assembly of Prion-like DomainsR35GM130352 · NIGMS · COLORADO STATE UNIVERSITY · PI Eric D Ross · 2019 to 2026
$3.1M
National Institute of General Medical Sciences (US) R35GM130352NIGMS NIH HHS R35 GM130352
6 · The paper itself

Abstract

Serine-arginine (SR) protein kinases regulate diverse cellular activities, including various steps in RNA maturation and transport. The yeast Saccharomyces cerevisiae expresses a single SR kinase, Sky1. Sky1 has a bipartite kinase domain, separated by an aggregation-prone prion-like domain (PrLD). The assembly of PrLDs is involved in the formation of various membraneless organelles, including stress granules; stress granules are reversible ribonucleoprotein assemblies that form in response to a variety of stresses. Here, we review a recent study suggesting that Sky1's PrLD promotes Sky1 recruitment to stress granules, and that Sky1 regulates stress granule dissolution by phosphorylating the RNA-shuttling protein Npl3.

Indexed as

Cytoplasmic GranulesOrganellesPhosphorylationPrionsProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsPrionsProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsSKY1 protein, S cerevisiaeKinasePrion-likeProtein aggregationStress granule

Identifiers

PMID31745569
PMCPMC7493465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.