ArticleJournal of the Endocrine Society2019
MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold.
Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Meal-Induced Proton Density Fat Fraction andNMR in biomedicine · 2026Article
- Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk.Current obesity reports · 2026Review
- Feasibility, reproducibility, and cold-induced energy expenditure using whole-room calorimetry in adults and children.Journal of the Endocrine Society · 2026Article
- Motion-robust proton density fat fraction andMagma (New York, N.Y.) · 2026Article
- Cold exposure and thermoneutrality similarly reduce supraclavicular brown adipose tissue fat fraction in fasted young lean adults.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Tracers and Imaging of Fatty Acid and Energy Metabolism of Human Adipose Tissues.Physiology (Bethesda, Md.) · 2024Review
- Automatic segmentation of human supraclavicular adipose tissue using high-resolution T2-weighted magnetic resonance imaging.Magma (New York, N.Y.) · 2023Article
- Automated segmentation of the human supraclavicular fat depot via deep neural network in water-fat separated magnetic resonance images.Quantitative imaging in medicine and surgery · 2023Article
- A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.Science immunology · 2023Article
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome.Cell reports. Medicine · 2022Article
- The involvement of the adrenergic nervous system in activating human brown adipose tissue and browning.Hormones (Athens, Greece) · 2022Review
- Intraindividual difference between supraclavicular and subcutaneous proton density fat fraction is associated with cold-induced thermogenesis.Quantitative imaging in medicine and surgery · 2022Article
- Practical application of in vivo MRI-based brown adipose tissue measurements in infants.Obesity (Silver Spring, Md.) · 2021Article
- Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota.Cell reports. Medicine · 2021Article
- Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021Review
- Low-doseEJNMMI research · 2020Article
- Substrate Utilization by Brown Adipose Tissue: What's Hot and What's Not?Frontiers in endocrinology · 2020Review
- Metabolic Improvement via Enhancing Thermogenic Fat-Mediated Non-shivering Thermogenesis: From Rodents to Humans.Frontiers in endocrinology · 2020Review
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextIn rodents, cold exposure induces the activation of brown adipose tissue (BAT) and the induction of intracellular triacylglycerol (TAG) lipolysis. However, in humans, the kinetics of supraclavicular (SCV) BAT activation and the potential importance of TAG stores remain poorly defined.
objectiveTo determine the time course of BAT activation and changes in intracellular TAG using MRI assessment of the SCV (
designCross-sectional.
settingClinical research center. PATIENTS OR OTHER
participantsTwelve healthy male volunteers aged 18 to 29 years [body mass index = 24.7 ± 2.8 kg/m
interventionsStandardized whole-body cold exposure (180 minutes at 18°C) and immediate rewarming (30 minutes at 32°C).
main outcome measuresProton density fat fraction (PDFF) and T2* of the SCV and posterior neck fat pads. Acquisitions occurred at 5- to 15-minute intervals during cooling and subsequent warming.
resultsSCV PDFF declined significantly after only 10 minutes of cold exposure [-1.6% (SE: 0.44%;
conclusionsThe rapid cold-induced decline in SCV PDFF suggests that in humans BAT is activated quickly in response to cold and that TAG is a primary substrate.
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Registered trials
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