ReviewEye (London, England)2020
Heavy metal toxicity and the aetiology of glaucoma.
Review in Eye (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Comprehensive multi-method analysis of blood heavy metals and nutrient intake in myopia and high myopia.Journal of translational medicine · 2026Article
- Metallomic Analysis of Vitreous Humor of the Human Eye-A Post-Mortem Multielemental Study.International journal of molecular sciences · 2026Article
- Lipidomic and neurobehavioral alterations from developmental lead exposure in zebrafish.Journal of hazardous materials · 2026Article
- Gastrointestinal-Ocular Toxicity Following Systematic Ingestion of Nickel-Cadmium Contaminated Water in Wistar Rats Demonstrates Possible Health Complications Characterized by Oxidative Stress, Inflammatory and Histological Changes.Biological trace element research · 2025Article
- Machine learning prediction of glaucoma by heavy metal exposure: results from the National Health and Nutrition Examination Survey 2005 to 2008.Scientific reports · 2025Article
- Significant association between methyl mercury level and latent tuberculosis infection risk: a cross-sectional study.BMC pulmonary medicine · 2024Article
- Spatial Vision Inequalities: A Literature Review of the Impact of Place on Vision and Eye Health Outcomes.Translational vision science & technology · 2024Review
- Associations of heavy metal exposure with diabetic retinopathy in the U.S. diabetic population: a cross-sectional study.Frontiers in public health · 2024Article
- A review of common statistical methods for dealing with multiple pollutant mixtures and multiple exposures.Frontiers in public health · 2024Review
- Quantification of Metal(loid)s in Lubricating Eye Drops Used in the Treatment of Dry Eye Disease.Molecules (Basel, Switzerland) · 2023Article
- Ocular safety of intravitreal ethylene diamine tetra acetic acid (EDTA): An experimental feasibility study.Toxicology reports · 2023Article
- Mercury intoxication and ophthalmic involvement: An update review.Frontiers in toxicology · 2023Review
- Clinical association between trace elements of tear and dry eye metrics.Scientific reports · 2022Article
- Analysis of 275 DIY recipes for eye cosmetics and their possible safety issues.International journal of cosmetic science · 2022Article
- Cadmium exposure in US adults, research based on the National Health and Nutrition Examination Survey from 1988 to 2018.Environmental science and pollution research international · 2022Article
- Ocular and Systemic Factors Associated with Glaucoma.Journal of current glaucoma practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Despite recent advances, our understanding of the aetiological mechanisms underlying glaucoma remains incomplete. Heavy metals toxicity has been linked to the development of neurodegenerative diseases and various ocular pathologies. Given the similarities in pathophysiology between glaucoma and some neurodegenerative disorders, it is plausible that heavy metal toxicity may play a role in the development of glaucoma. Heavy metal exposure may be occupational, or through water or dietary contamination. In this report, we review mechanisms for systemic and neurotoxicity for arsenic, cadmium, chromium, cobalt, lead, mercury, and manganese, and weigh the evidence for an association between glaucoma and the accumulation of heavy metals either in ocular tissues or in the central nervous system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.