Evidence map›Paper›PMID 31745248›Full record

ArticleBone marrow transplantation2020

Predictors of the trajectory of cognitive functioning in the first 6 months after allogeneic hematopoietic stem cell transplantation.

Samantha J Mayo, Hans A Messner, Sean B Rourke, Doris Howell, J Charles Victor, Jeffrey H Lipton, J Kuruvilla, Vikas Gutpa, Dennis Dong Hwan Kim, Fotios V Michelis and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Late cognitive outcomes among allogeneic stem cell transplant survivors: follow-up data from a 6-year longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  6. Cognitive function in patients prior to undergoing allogeneic hematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Samantha J MayoLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada. Samantha.mayo@utoronto.ca.ORCID http://orcid.org/0000-0002-0083-5679
Hans A MessnerPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Sean B RourkeMAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Doris HowellLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada.
J Charles VictorInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Jeffrey H LiptonPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
J KuruvillaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Vikas GutpaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Dennis Dong Hwan KimPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Fotios V MichelisPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Kelly MetcalfeLawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada.
University Health Network · CAUniversity of Toronto · CASt. Michael's Hospital · CA

Funding

CIHR
6 · The paper itself

Abstract

Certain subgroups of patients may be particularly vulnerable to cognitive decline after treatment with allogeneic hematopoietic stem cell transplant (HCT). The objective of this study was to identify predictors of cognitive functioning changes within the first 6 months after HCT. Fifty-eight adults treated with allogeneic HCT (53% male, mean 48 years of age) completed neuropsychological tests of learning/memory, psychomotor efficiency/processing speed, and executive functioning/working memory at three time points: pre-HCT and day 100 and 6 months post transplant. On average, there was significant improvement in learning/memory (p = 0.002), psychomotor efficiency/processing speed (p < 0.0001), and executive functioning/working memory (p < 0.0001), at 6 months. Multilevel modeling identified predictors of divergence from this trajectory; Karnofsky performance status <80 was associated with worsening learning/memory over time; peak severity of acute graft-versus-host disease >=Grade 2 was associated with worsening psychomotor efficiency/processing speed; and greater years of education predicted a faster improvement in psychomotor efficiency/processing speed. Other factors were associated with cognitive functioning over time: higher intelligence quotient (IQ) was associated with better cognitive functioning, and older age, being male, and greater pretransplant comorbidities were associated with worse cognitive functioning. Overall, cognitive performance appears to improve over the first 6 months after transplant. However, pretransplant and posttransplant factors may influence this trajectory.

Indexed as

Cognition DisordersHematopoietic Stem Cell TransplantationAdultAgedCognitionExecutive FunctionFemaleHumansInfantMaleNeuropsychological Tests

Identifiers

PMID31745248
OpenAlexW2990681468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.