Evidence map›Paper›PMID 31745236›Full record

ArticleMolecular psychiatry2021

Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence.

Weida Meng, Louise K Sjöholm, Olga Kononenko, Nicole Tay, Dandan Zhang, Daniil Sarkisyan, Jennifer R Geske, Alex Ing, Wenqing Qiu, Hiroyuki Watanabe and 14 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Functional Consequences Paternal Preconceptual Alcohol Consumption.Current topics in behavioral neurosciences · 2025
    Review
  2. Review
  3. Epigenetic regulation ofFrontiers in psychiatry · 2025
    Article
  4. Article
  5. Human genetics and epigenetics of alcohol use disorder.The Journal of clinical investigation · 2024
    Review
  6. Article
  7. Article
  8. DNA Methylation NearPediatric diabetes · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Observational
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 8 countries.

Weida Meng *MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China.
Louise K Sjöholm *Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Olga Kononenko *Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Nicole Tay *Centre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1307-408X
Dandan Zhang *MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China.
Daniil Sarkisyan *Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Jennifer R GeskeDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-7341-1535
Alex IngCentre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Wenqing QiuMOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China.
Hiroyuki WatanabeDivision of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Radwa AlmamounDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Helge FrielingDepartment of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany.
Stefan BleichDepartment of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany.
Donghong CuiShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Joanna M BiernackaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9350-4440
R Dayne MayfieldThe Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX, USA.
Yongjun DangMOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China.
Victor M KarpyakDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7740-6469
IMAGEN Consortium
Georgy Bakalkin *Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Tomas J Ekström *Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. tomas.ekstrom@ki.se.ORCID http://orcid.org/0000-0002-3747-1581
Joelle Rüegg *Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Yun Liu *MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, China. yliu39@fudan.edu.cn.ORCID http://orcid.org/0000-0001-5753-1265
King's College London · GBHeidelberg University · DEKarolinska Institutet · SESun Yat-sen University · CNUppsala University · SEInserm · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHumboldt-Universität zu Berlin · DEMayo Clinic · USMedizinische Hochschule Hannover · DETechnische Universität Dresden · DETrinity College Dublin · IEFudan University · CNMayo Clinic in Florida · USPhysikalisch-Technische Bundesanstalt · DEShanghai Jiao Tong University · CNThe University of Texas at Austin · USUniversité Paris-Sud · FRUniversity of Göttingen · DEUniversity of Mannheim · DE

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Department of HealthMedical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH085772
6 · The paper itself

Abstract

Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence. Methylation within DMR-DLGAP2 was found to be genotype-dependent, allele-specific and associated with reward processing in brain. Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls. These results suggest that DLGAP2 may be an interface for genetic and epigenetic factors controlling alcohol use and dependence.

Indexed as

Alcohol DrinkingDNA MethylationEpigenesis, GeneticAlcoholismAnimalsEpigenomeGenotypeMiceNerve Tissue ProteinsDlgap2 protein, mouseNerve Tissue Proteins

Identifiers

PMID31745236
OpenAlexW2990882070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.