ArticleScientific reports2019
Associations of parental age with offspring all-cause and cause-specific adult mortality.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Associations of paternal age with offspring under-five mortality and perinatal outcomes: a cohort study using claims data in Taiwan.BMJ public health · 2024Article
- Early life events may be the first steps on the multistep path to amyotrophic lateral sclerosis.Scientific reports · 2024Article
- Limiting access to assisted reproductive technologies for males of advanced age-Pros and cons from a Nordic perspective.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Building a family at advanced parental age: a systematic review on the risks and opportunities for parents and their offspring.Human reproduction open · 2023Review
- Parental distress rating at the child's age of 15 years predicts probable mental diagnosis: a three-year follow-up.BMC pediatrics · 2022Article
- Early Development of Cardiac Fibrosis in Young Old-Father Offspring.Oxidative medicine and cellular longevity · 2022Article
- A Nation-Wide Swedish Cohort Study on Early Maternal Age at First Childbirth and Risk for Offspring Deaths, Accidents, and Suicide Attempts.Behavior genetics · 2022Article
- Parental age at conception on mouse lemur's offspring longevity: Sex-specific maternal effects.PloS one · 2022Article
- Childhood vaccination uptake and associated factors among children 12-23 months in rural settings of the Gambia: a community-based cross-sectional study.BMC public health · 2021Article
- Inhibition of the NLRP3 inflammasome prevents ovarian aging.Science advances · 2021Article
- Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.Reproductive biology and endocrinology : RB&E · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
People are having children later in life. The consequences for offspring adult survival have been little studied due to the need for long follow-up linked to parental data and most research has considered offspring survival only in early life. We used Swedish registry data to examine all-cause and cause-specific adult mortality (293,470 deaths among 5,204,433 people, followed up to a maximum of 80 years old) in relation to parental age. For most common causes of death adult survival was improved in the offspring of older parents (HR for all-cause survival was 0.96 (95% CI: 0.96, 0.97) and 0.98 (0.97, 0.98) per five years of maternal and paternal age, respectively). The childhood environment provided by older parents may more than compensate for any physiological disadvantages. Within-family analyses suggested stronger benefits of advanced parental age. This emphasises the importance of secular trends; a parent's later children were born into a wealthier, healthier world. Sibling-comparison analyses can best assess individual family planning choices, but our results suggested a vulnerability to selection bias when there is extensive censoring. We consider the numerous causal and non-causal mechanisms which can link parental age and offspring survival, and the difficulty of separating them with currently available data.
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