Evidence map›Paper›PMID 31745217›Full record

ArticleScientific reports2019

Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction.

Amparo Urios, Felipe Ordoño, Raquel García-García, Alba Mangas-Losada, Paola Leone, Juan José Gallego, Andrea Cabrera-Pastor, Javier Megías, Juan Fermin Ordoño, Vicente Felipo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  15. Effect of Asthma on Erectile Dysfunction in Rats as Determined by Biological Network Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Amparo UriosFundación Investigación Hospital Clínico Valencia, INCLIVA, Valencia, Spain.
Felipe OrdoñoServicio Urología, Hospital Arnau Vilanova, Valencia, Spain.
Raquel García-GarcíaLaboratorio de Neurobiologia, Centro Investigación Príncipe Felipe, Valencia, Spain.
Alba Mangas-LosadaFundación Investigación Hospital Clínico Valencia, INCLIVA, Valencia, Spain.
Paola LeoneLaboratorio de Neurobiologia, Centro Investigación Príncipe Felipe, Valencia, Spain.
Juan José GallegoFundación Investigación Hospital Clínico Valencia, INCLIVA, Valencia, Spain.
Andrea Cabrera-PastorFundación Investigación Hospital Clínico Valencia, INCLIVA, Valencia, Spain.ORCID http://orcid.org/0000-0002-0729-1045
Javier MegíasDepartamento Patología, Facultad Medicina, Universidad Valencia, Valencia, Spain.
Juan Fermin OrdoñoServicio Neurofisiología, Hospital Arnau Vilanova, Valencia, Spain, Psychopatology and Neurophysiology Unit, Paterna Mental Health Center, CIBERSAM, Valencia, Spain.
Vicente FelipoLaboratorio de Neurobiologia, Centro Investigación Príncipe Felipe, Valencia, Spain.ORCID http://orcid.org/0000-0003-3145-9538
Carmina MontoliuFundación Investigación Hospital Clínico Valencia, INCLIVA, Valencia, Spain. cmontoliu@incliva.es.
INCLIVA Health Research Institute · ESCentro de Investigacion Principe Felipe · ESUniversitat de València · ESCentro de Investigación Biomédica en Red de Salud Mental · ESHospital Arnau de Vilanova · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with Benign prostatic hyperplasia, low urinary tract symptoms, and erectile dysfunction (BPH/LUTS-ED) present chronic inflammation. We studied in patients with BPH/LUTS-ED the effect of tadalafil treatment (5 mg/day) on changes in peripheral inflammation, cognitive function, and the auditory evoked potential, "mismatch negativity" (MMN). Nine patients with BPH/LUTS-ED and 12 controls performed psychometric tests, MMN. IL-6, IL-17, IL-18, cGMP and CD4

Indexed as

AgedCognitionErectile DysfunctionHumansInflammationLower Urinary Tract SymptomsMaleMiddle AgedPhosphodiesterase 5 InhibitorsProstatic HyperplasiaTadalafilTreatment OutcomePhosphodiesterase 5 InhibitorsTadalafil

Identifiers

PMID31745217
PMCPMC6863868
OpenAlexW2991518823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.