Evidence map›Paper›PMID 31744921›Full record

ArticlemBio2019

Functional Multigenomic Screening of Human-Associated Bacteria for NF-κB-Inducing Bioactive Effectors.

Andreia B Estrela, Toshiki G Nakashige, Christophe Lemetre, Ian D Woodworth, Jazz L Weisman, Louis J Cohen, Sean F Brady

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andreia B EstrelaLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.
Toshiki G NakashigeLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.
Christophe LemetreLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.
Ian D WoodworthLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.
Jazz L WeismanLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA.
Louis J CohenDivision of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sean F BradyLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA sbrady@rockefeller.edu.
Rockefeller University · USIcahn School of Medicine at Mount Sinai · US

Funding

Discovery of GPCR-active natural products and their biosynthetic genes from the human associated bacteriaR01AT009562 · NCCIH · ROCKEFELLER UNIVERSITY · PI BRADY, SEAN F · 2017 to 2021
$2.2M
NCCIH NIH HHS R01 AT009562
6 · The paper itself

Abstract

The effect of the microbiota on its human host is driven, at least in part, by small-molecule and protein effectors it produces. Here, we report on the use of functional multigenomic screening to identify microbiota-encoded effectors. In this study, genomic DNA from 116 human-associated bacteria was cloned

Indexed as

Genome, BacterialMetagenomicsBacteriaBacterial InfectionsGene Expression Regulation, BacterialGene LibraryHumansMicrobiotaNF-kappa BOperonPhylogenyNF-kappa Bfunctional screeninghuman microbiomeNF-κB

Identifiers

PMID31744921
PMCPMC6867899
OpenAlexW2984136829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.