ArticleThe European respiratory journal2020
Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension.
Open access · hybridAbstract readMulticenter Study
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Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Supplementation with Iron in Pulmonary Arterial Hypertension. Two Randomized Crossover Trials.Annals of the American Thoracic Society · 2021Trial
- Development and validation of an interpretable machine learning model for pulmonary heart disease in patients with pneumoconiosis.Frontiers in public health · 2026Article
- Evaluating NT-proBNP-to-Albumin (NTAR) and RDW-to-eGFR (RGR) Ratios as Biomarkers for Predicting Hospitalization Duration and Mortality in Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH).Diagnostics (Basel, Switzerland) · 2025Article
- Serum proteomics identify biomarkers and pathogenesis of portopulmonary hypertension diagnosed based on echocardiography.Scientific reports · 2025Article
- The relationship between red blood cell distribution width and long-term prognosis of asthma: a population-based study.Scientific reports · 2025Article
- Causal association between remnant cholesterol level and risk of cardiovascular diseases: a bidirectional two sample mendelian randomization study.Scientific reports · 2024Article
- Genetics and precision genomics approaches to pulmonary hypertension.The European respiratory journal · 2024Review
- Immature reticulocyte fraction: A novel biomarker of hemodynamic severity in pulmonary arterial hypertension.Pulmonary circulation · 2024Article
- No genetic causal association between iron status and pulmonary artery hypertension: Insights from a two-sample Mendelian randomization.Pulmonary circulation · 2024Article
- Mendelian Randomization in Pulmonary Arterial Hypertension: Unveiling Early Insights With Promise for Future Discoveries.Journal of the American Heart Association · 2024Article
- Eye signs as a novel risk predictor in pulmonary arterial hypertension associated with systemic lupus erythematosus.Advances in rheumatology (London, England) · 2024Observational
- Ratio of hemoglobin to red cell distribution width: an inflammatory predictor of survival in AIDS-related DLBCL.Frontiers in immunology · 2024Article
- Assessing causal associations of blood counts and biochemical indicators with pulmonary arterial hypertension: a Mendelian randomization study and results from national health and nutrition examination survey 2003-2018.Frontiers in endocrinology · 2024Observational
- Intravenous iron supplementation in pulmonary hypertension groups 1 to 4.International journal of medical sciences · 2024Article
- Circulating extracellular vesicles as novel biomarkers for pulmonary arterial hypertension in patients with systemic lupus erythematosus.Frontiers in immunology · 2024Article
- Exploring regression dilution bias using repeat measurements of 2858 variables in ≤49 000 UK Biobank participants.International journal of epidemiology · 2023Article
- Red cell distribution width-a potential prognostic indicator for colorectal cancer patients after radical resection in China.Journal of gastrointestinal oncology · 2023Article
- A promising prognostic model for predicting survival of patients with HIV-related diffuse large B-cell lymphoma in the cART era.Cancer medicine · 2023Observational
- Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension.Circulation research · 2022Review
- An Overview of Circulating Pulmonary Arterial Hypertension Biomarkers.Frontiers in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
22 authors at 13 institutions in 3 countries.
Anna UlrichNational Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.
John WhartonNational Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.
Timothy E ThayerVanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA.
Emilia M SwietlikDept of Medicine, University of Cambridge, Cambridge, UK.
Tufik R AssadWilliamson Country Medical Center, Franklin, TN, USA.
Ankit A DesaiDept of Medicine, Indiana University, Indianapolis, IN, USA.
Stefan GräfDept of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1315-8873
Lars HarbaumNational Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.
Marc HumbertUniversité Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Paris, France.ORCID 0000-0003-0703-2892
Nicholas W MorrellDept of Medicine, University of Cambridge, Cambridge, UK.
William C NicholsDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Dept of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Florent SoubrierSorbonne Universités, UPMC Univ. Paris 06, Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris, France.ORCID 0000-0003-2571-7932
Laura SouthgateMolecular and Clinical Sciences Research Institute, St George's University of London, London, UK.ORCID 0000-0002-2090-1450
David-Alexandre TrégouëtINSERM UMR_S 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Richard C TrembathDivision of Genetics and Molecular Medicine, King's College London, London, UK.
Evan L BrittainVanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA.
Martin R WilkinsNational Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK.
Inga ProkopenkoDept of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.
Christopher J RhodesNational Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK crhodes@imperial.ac.uk.
NIHR BioResource – Rare Diseases Consortium
UK PAH Cohort Study Consortium
US PAH Biobank Consortium
Imperial College London · GBUniversity of Cambridge · GBVanderbilt University Medical Center · USCincinnati Children's Hospital Medical Center · USHammersmith Hospital · GBIndiana University – Purdue University Indianapolis · USInserm · FRKing's College London · GBSt George's, University of London · GBUniversité de Bordeaux · FRUniversité Paris-Sud · FRUniversity of Surrey · GBWilliamson College · US
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0MNational Biological Sample and Data Repository for PAHR24HL105333 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI NICHOLS, WILLIAM C · 2012 to 2016
$10.1MThe Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MVESPA: Vanderbilt Electronic Systems for Pharmacogenomic AssessmentRC2GM092618 · NIGMS · VANDERBILT UNIVERSITY · PI DENNY, JOSHUA C., RODEN, DAN M · 2009 to 2010
$6.4MVanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0MClinical, Genetic, and Proteomic Risk Factors for Pulmonary Hypertension in Heart FailureR01HL146588 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L, FREIBERG, MATTHEW S · 2019 to 2022
$3.4MUnderstanding the genetic risk underlying racial disparities in uterine fibroids - Diversity SupplementR01HD074711 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VELEZ EDWARDS, DIGNA R · 2013 to 2017
$2.9MBritish Heart Foundation CH/09/001/25945British Heart Foundation FS/15/59/31839British Heart Foundation RE/18/4/34215British Heart Foundation RG/08/006/25302British Heart Foundation RG/10/16/28575British Heart Foundation RG/13/4/30107British Heart Foundation SP/12/12/29836Medical Research Council MR/K020919/1NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R01 HL146588NHLBI NIH HHS R24 HL105333NHLBI NIH HHS U19 HL065962NICHD NIH HHS R01 HD074711NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NINDS NIH HHS R01 NS032830Wellcome TrustWellcome Trust 204809/Z/16/Z
Abstract
Pulmonary arterial hypertension (PAH) is a rare disease that leads to premature death from right heart failure. It is strongly associated with elevated red cell distribution width (RDW), a correlate of several iron status biomarkers. High RDW values can signal early-stage iron deficiency or iron deficiency anaemia. This study investigated whether elevated RDW is causally associated with PAH.A two-sample Mendelian randomisation (MR) approach was applied to investigate whether genetic predisposition to higher levels of RDW increases the odds of developing PAH. Primary and secondary MR analyses were performed using all available genome-wide significant RDW variants (n=179) and five genome-wide significant RDW variants that act
Indexed as
Hypertension, PulmonaryPulmonary Arterial HypertensionCase-Control StudiesErythrocyte IndicesGenome-Wide Association StudyHumans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.