ArticleArchives of disease in childhood2019
Screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials.
Article in Archives of disease in childhood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe global impact of artemisinin-based combination therapies on malaria-associated mortality and their origins in ancient Chinese medicine has heightened interest in the natural discovery of future antimalarials.
methodsA double-blind study to identify potential ingredients with antimalarial activity from traditional remedies with reported antipyretic properties. Recipes of clear broths, passed down by tradition in families of diverse ethnic origin, were sourced by school children. Broths were then tested for their ability to arrest malaria parasite asexual growth or sexual stage development in vitro. Clear broth extract was incubated with in vitro cultures of
resultsOf the 56 broths tested, 5 were found to give >50% in vitro growth inhibition against
conclusionsThis screening approach succeeded in finding broths with activity against malaria parasite
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