Evidence map›Paper›PMID 31744630›Full record

ArticleTrends in neurosciences2020

Travelling Together: A Unifying Pathomechanism for ALS.

Pietro Fratta, Nicol Birsa, Andrew P Tosolini, Giampietro Schiavo

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Pietro FrattaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: p.fratta@ucl.ac.uk.
Nicol BirsaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK.
Andrew P TosoliniDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Giampietro SchiavoDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK; Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK. Electronic address: giampietro.schiavo@ucl.ac.uk.
National Hospital for Neurology and Neurosurgery · GBUK Dementia Research Institute · GBUniversity College London · GB

Funding

Medical Research Council G1000287Medical Research Council MR/M008606/1Medical Research Council MR/S006508/1Motor Neurone Disease Association FRATTA/JAN15/946-795
6 · The paper itself

Abstract

Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting that RNA granules 'hitchhike' on LAMP1-positive organelles using annexin A11 as a tether.

Indexed as

Amyotrophic Lateral SclerosisAnnexinsAxonal TransportHumansLysosomesOrganellesRNAAnnexinsRNAamyotrophic lateral sclerosisannexin A11axonal transportLAMP1-positive organellesRNA granules

Identifiers

PMID31744630
OpenAlexW2988604650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.