Evidence map›Paper›PMID 31744537›Full record

ArticleStem cell research & therapy2019

Antler stem cell-conditioned medium stimulates regenerative wound healing in rats.

Xiaoli Rong, Wenhui Chu, Haiying Zhang, Yusu Wang, Xiaoyan Qi, Guokun Zhang, Yimin Wang, Chunyi Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Xiaoli RongChangchun Sci-Tech University, 1699 DongHua St., Shuangyang District, Changchun, Jilin, 130022, China.
Wenhui ChuSchool of Life Science, Taizhou University, Taizhou, 318000, China.
Haiying ZhangKey Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, 828 Xinmin St., Changchun, Jilin, 130021, China.
Yusu WangCollege of Chinese Medicinal Materials, Jilin Agricultural University, 2888 XinCheng St., Changchun, Jilin, 130118, China.
Xiaoyan QiInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, 4899 Juye St., Changchun, Jilin, 130112, China.
Guokun ZhangInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, 4899 Juye St., Changchun, Jilin, 130112, China.
Yimin WangThe Scientific Research Center, China-Japan Union Hospital of Jilin University, 126 Xiantai St., Changchun, Jilin, 130033, China. yiminwang@hotmail.com.
Chunyi LiChangchun Sci-Tech University, 1699 DongHua St., Shuangyang District, Changchun, Jilin, 130022, China. lichunyi1959@163.com.
Chinese Academy of Agricultural Sciences · CNJilin University · CNInstitute of Special Animal and Plant Sciences · CNJilin Agricultural University · CNTaizhou University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhen the deer antler is cast, it leaves a cutaneous wound that can achieve scarless healing due to the presence of antler stem cells (ASCs). This provides an opportunity to study regenerative wound healing.

methodsIn this study, we investigated the therapeutic effects and mechanism of antler stem cell-conditioned medium (ASC-CM) on cutaneous wound healing in rats. In vitro, we investigated the effects of the ASC-CM on proliferation of HUVEC and NIH-3T3 cell lines. In vivo, we evaluated the effects of ASC-CM on cutaneous wound healing using full-thickness skin punch-cut wounds in rats.

resultsThe results showed that ASC-CM significantly stimulated proliferation of the HUVEC and NIH-3T3 cells in vitro. In vivo, completion of healing of the rat wounds treated with ASC-CM was on day 16 (± 3 days), 9 days (± 2 days) earlier than the control group (DMEM); the area of the wounds treated with ASC-CM was significantly smaller (p < 0.05) than the two control groups. Further molecular characterization showed that the ratios of Col3A1/Col1A2, TGF-β3/TGF-β1, MMP1/TIMP1, and MMP3/TIMP1 significantly increased (p < 0.01) in the healed tissue in the ASC-CM group.

conclusionsIn conclusion, ASC-CM effectively accelerated the wound closure rate and enhanced the quality of healing, which might be through transforming wound dermal fibroblasts into the fetal counterparts. Therefore, the ASC-CM may have potential to be developed as a novel cell-free therapeutic for scarless wound healing.

Indexed as

AnimalsAntlersCell ProliferationCulture Media, ConditionedEpidermal Growth FactorFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsKi-67 AntigenMiceNIH 3T3 CellsRats, Sprague-DawleyRegenerationSolubilityStem CellsCulture Media, ConditionedEpidermal Growth FactorKi-67 AntigenAntler stem cellsCell proliferationConditioned mediumScarless healingSkin regeneration

Identifiers

PMID31744537
PMCPMC6862758
OpenAlexW2990713525

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.