Evidence map›Paper›PMID 31744508›Full record

ArticleJournal of hematology & oncology2019

Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study.

Alice Ramassone, Andrea D'Argenio, Angelo Veronese, Alessio Basti, Shimaa Hassan AbdelAziz Soliman, Stefano Volinia, Cristian Bassi, Sara Pagotto, Manuela Ferracin, Laura Lupini and 12 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematology & oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 2 countries.

Alice RamassoneUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Andrea D'ArgenioUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Angelo VeroneseUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Alessio BastiDepartment of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Shimaa Hassan AbdelAziz SolimanUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Stefano VoliniaDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Cristian BassiDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Sara PagottoUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Manuela FerracinDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Laura LupiniDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Elena SaccentiDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Veronica BalattiDepartment of Cancer Biology and Genetics and Comprehensive Cancer Center at the Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Felice PepeUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Laura Z RassentiDepartment of Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA.
Idanna InnocentiFondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Francesco AutoreFondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Laura MarzettiDepartment of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Renato Mariani-CostantiniUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
Thomas J KippsDepartment of Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA.
Massimo NegriniDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Luca LaurentiFondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Rosa VisoneUnit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d'Annunzio Chieti-Pescara, Chieti, Italy. r.visone@unich.it.
University of Chieti-Pescara · ITUniversity of Ferrara · ITAgostino Gemelli University Polyclinic · ITMoores Cancer CenterIstituti di Ricovero e Cura a Carattere Scientifico · ITThe Ohio State University Wexner Medical Center · USUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.

Indexed as

Chromosome AberrationsClonal EvolutionMutationBiomarkers, TumorDisease ProgressionHumansLeukemia, Lymphocytic, Chronic, B-CellLongitudinal StudiesPrognosisSurvival RateBiomarkers, TumorChronic lymphocytic leukemiaClonal evolutionCopy number variationNucleotide variation

Identifiers

PMID31744508
PMCPMC6862808
OpenAlexW2990980789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.