Evidence map›Paper›PMID 31744505›Full record

ArticleCell communication and signaling : CCS2019

Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein.

Rachel NeMoyer, Arindam Mondal, Mehul Vora, Elaine Langenfeld, Danea Glover, Michael Scott, Lauren Lairson, Christopher Rongo, David J Augeri, Youyi Peng and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Rachel NeMoyerDepartment of Surgery, Rutgers Robert Wood Johnson Medical School, The State University of New Jersey, New Brunswick, NJ, 08903, USA.
Arindam MondalDepartment of Surgery, Rutgers Robert Wood Johnson Medical School, The State University of New Jersey, New Brunswick, NJ, 08903, USA.
Mehul VoraDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
Elaine LangenfeldDepartment of Surgery, Rutgers Robert Wood Johnson Medical School, The State University of New Jersey, New Brunswick, NJ, 08903, USA.
Danea GloverRBHS Rutgers Biomedical and Health Sciences, Rutgers University, Piscataway, NJ, 08854, USA.
Michael ScottDepartment of Surgery, Rutgers Robert Wood Johnson Medical School, The State University of New Jersey, New Brunswick, NJ, 08903, USA.
Lauren LairsonRutgers University, Piscataway, NJ, 08854, USA.
Christopher RongoDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
David J AugeriErnest Mario School of Pharmacy, Rutgers Translational Science, Rutgers University, Piscataway, NJ, 08854, USA.
Youyi PengBiomedical Informatics Shared Resources, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA.
Salma K JabbourDepartment of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA.
John LangenfeldDepartment of Surgery, Rutgers Robert Wood Johnson Medical School, The State University of New Jersey, New Brunswick, NJ, 08903, USA. langenje@cinj.rutgers.edu.
Rutgers, The State University of New Jersey · USJohnson University · USRutgers Cancer Institute of New Jersey

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
Genetics Analysis of Neuronal Hypoxic Stress ResistanceR01GM101972 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI RONGO, CHRISTOPHER G · 2012 to 2024
$4.1M
Targeting BMP type 2 receptor for the treatment of breast cancer.R01CA225830 · NCI · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI LANGENFELD, JOHN · 2018 to 2022
$3.2M
Supercomputing: Rutgers' Catalyst for Discovery at the Frontiers of MedicineS10OD012346 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI MICHELSON, LESLIE PAUL · 2015 to 2015
$1.7M
NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA225830NIGMS NIH HHS R01 GM101972NIH HHS S10 OD012346
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Down-RegulationA549 CellsApoptosis Regulatory ProteinsBone Morphogenetic Protein Receptors, Type IICell DeathCell SurvivalCytosolEnzyme InhibitorsHumansLung NeoplasmsMitochondrial ProteinsSignal TransductionTumor Cells, CulturedX-Linked Inhibitor of Apoptosis ProteinApoptosis Regulatory ProteinsBMPR2 protein, humanBone Morphogenetic Protein Receptors, Type IIDIABLO protein, humanEnzyme InhibitorsMitochondrial ProteinsXIAP protein, humanX-Linked Inhibitor of Apoptosis Protein

Identifiers

PMID31744505
PMCPMC6862756
OpenAlexW2990841611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.