Evidence map›Paper›PMID 31744426›Full record

ArticleStroke2020

Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy.

Aaron M Gusdon, Paul A Nyquist, Victor M Torres-Lopez, Audrey C Leasure, Guido J Falcone, Kevin N Sheth, Lauren H Sansing, Daniel F Hanley, Rachna Malani

Open access · greenAbstract read
In one paragraph

Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Aaron M GusdonFrom the Division of Neurocritical Care, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (A.M.G., P.A.N.).
Paul A NyquistFrom the Division of Neurocritical Care, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (A.M.G., P.A.N.).
Victor M Torres-LopezDepartment of Neurology, Yale University School of Medicine, New Haven, CT (V.M.T.-L., A.C.L., G.J.F., K.N.S., L.H.S.).
Audrey C LeasureDepartment of Neurology, Yale University School of Medicine, New Haven, CT (V.M.T.-L., A.C.L., G.J.F., K.N.S., L.H.S.).
Guido J FalconeDepartment of Neurology, Yale University School of Medicine, New Haven, CT (V.M.T.-L., A.C.L., G.J.F., K.N.S., L.H.S.).
Kevin N ShethDepartment of Neurology, Yale University School of Medicine, New Haven, CT (V.M.T.-L., A.C.L., G.J.F., K.N.S., L.H.S.).
Lauren H SansingDepartment of Neurology, Yale University School of Medicine, New Haven, CT (V.M.T.-L., A.C.L., G.J.F., K.N.S., L.H.S.).
Daniel F HanleyDivision of Brain Injury Outcomes (BIOS), Johns Hopkins University School of Medicine, Baltimore, MD (P.A.N., D.F.H.).
Rachna MalaniDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY (R.M.).
Yale University · USJohns Hopkins University · USJohns Hopkins Medicine · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Johns Hopkins-Tufts Trial Innovation Center HEAL Pain ERN SupplementU24TR001609 · NCATS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2016 to 2022
$36.3M
MISTIE III_ Lead Grant_ Cluster Application for the Clinical Coordinating CenterU01NS080824 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2013 to 2017
$23.2M
Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6M
The Recovery in Stroke Using PAP (RISE UP) StudyR01NR018335 · NINR · YALE UNIVERSITY · PI REDEKER, NANCY S, SHETH, KEVIN NAVIN · 2019 to 2023
$3.4M
Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0M
Dynamic Neuroimmune Profiling in Patients with Acute Intracerebral HemorrhageR01NS097728 · NINDS · YALE UNIVERSITY · PI SANSING, LAUREN H · 2016 to 2020
$2.8M
Improved glyburide therapy via acid- triggered release functional nanoparticles and therapeutic imagingR01NS110721 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, ZHOU, JIANGBING · 2019 to 2023
$1.9M
Efferocytosis and the resolution of inflammation after intracerebral hemorrhageR01NS095993 · NINDS · YALE UNIVERSITY · PI SANSING, LAUREN H · 2016 to 2020
$1.8M
Yale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)U24NS107136 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, SPUDICH, SERENA S · 2018 to 2022
$1.7M
NCATS NIH HHS U24 TR001609NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NIA NIH HHS K76 AG059992NIA NIH HHS P30 AG021342NINDS NIH HHS R01 NS095993NINDS NIH HHS R01 NS097728NINDS NIH HHS R01 NS110721NINDS NIH HHS R03 NS112859NINDS NIH HHS R21 NS088972NINDS NIH HHS U01 NS080824NINDS NIH HHS U01 NS106513NINDS NIH HHS U24 NS107136NINDS NIH HHS U24 NS107215NINR NIH HHS R01 NR018335
6 · The paper itself

Abstract

Background and Purpose- Patients with active malignancy are at risk for intracerebral hemorrhage (ICH). We aimed to characterize perihematomal edema (PHE) and hematoma volumes after spontaneous nontraumatic ICH in patients with cancer without central nervous system involvement. Methods- Patients with active malignancy who developed ICH were retrospectively identified through automated searches of institutional databases. Control patients were identified with ICH and without active cancer. Demographic and cancer-specific data were obtained by chart review. Hematoma and PHE volumes were determined using semiautomated methodology. Univariate and multivariate linear regression models were created to assess which variables were associated with hematoma and PHE expansion. Results- Patients with cancer (N=80) and controls (N=136) had similar demographics (all

Indexed as

AgedBrain EdemaCerebral HemorrhageEdemaFemaleHematomaHumansMaleMiddle AgedNeoplasmsRetrospective StudiesSeverity of Illness Indexcentral nervous systemcerebral hemorrhageedemahematomaplatelet transfusion

Identifiers

PMID31744426
PMCPMC7048624
OpenAlexW2989919451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.