Evidence map›Paper›PMID 31744375›Full record

ArticleJournal of medical screening2020

Cervical screening in Western Kazakhstan: Liquid-based cytology 'Cell Scan' versus azur-eosin staining.

Saule Balmagambetova, Giovanni Gabutti, Arip Koyshybaev, Cecilia Acuti Martellucci, Olzhas Urazayev, Kanshaiym Sakiyeva, Karlygash Bekova

Abstract readComparative Study
In one paragraph

Article in Journal of medical screening, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saule BalmagambetovaOncology Department, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.ORCID 0000-0003-4080-5383
Giovanni GabuttiDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Arip KoyshybaevOncology Department, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Cecilia Acuti MartellucciPostgraduate School of Hygiene and Preventive Medicine, University of Ferrara, Ferrara, Italy.ORCID 0000-0002-4308-2144
Olzhas UrazayevOncology Department, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Kanshaiym SakiyevaObstetrics and Gynaecology Department, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Karlygash BekovaWest Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the effectiveness of the current cervical cancer screening tools in Western Kazakhstan.

methodsSmears taken through (i) conventional cytology using azur-eosin staining and (ii) liquid-based cytology (LBC) 'Cell Scan' in the general female population and in women first diagnosed with cervical cancer were collected throughout the region. ROC-analysis with curve construction and weighted Cohen's κ calculation were applied. A total of 494 cytological pairs were collected, including 94 sets with histology findings.

resultsThe conventional (azur-eosin staining) technique contained 0.2% non-informative material and LBC 'Cell Scan' had 5.9%. Area under the curve was 0.95 for the conventional technique and 0.92 for 'Cell Scan' (

conclusionsIn this analysis it was not possible to prove that the LBC 'Cell Scan' technique was superior to its predecessor, azur-eosin staining. These findings highlight the need to modify the current screening programme according to updated international scientific evidence on effective screening design, such as the use of HPV DNA testing with Pap smear triage in women aged 30 or older. Further research, and a Health Technology Assessment, are necessary if we wish to establish a national standardized screening programme using the available technology appropriately.

Indexed as

Azure StainsAdolescentAdultArea Under CurveCytological TechniquesEarly Detection of CancerEosine Yellowish-(YS)FemaleFluorescent DyesHumansKazakhstanMiddle AgedPapanicolaou TestROC CurveStaining and LabelingUterine Cervical NeoplasmsAzure StainsEosine Yellowish-(YS)Fluorescent Dyesazur-eosin staining‘Cell Scan’ preservative fluidscervical screeningcytologyKazakhstan

Identifiers

PMID31744375
PMCPMC7433700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.