Evidence map›Paper›PMID 31744230›Full record

ReviewInternational journal of molecular sciences2019

p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer.

Artem Smirnov, Lucia Anemona, Flavia Novelli, Cristina M Piro, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Eleonora Candi

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. p53 Family in Resistance to Targeted Therapy of Melanoma.International journal of molecular sciences · 2022
    Review
  16. The Splicing Factor PTBP1 RepressesCancer research communications · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Artem SmirnovDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-1575-8725
Lucia AnemonaDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-3711-2714
Flavia NovelliDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-3746-7478
Cristina M PiroDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-3004-367X
Margherita Annicchiarico-PetruzzelliIstituto Dermopatico dell'Immacolata-IRCCS, 00163 Rome, Italy.ORCID 0000-0002-4717-4740
Gerry MelinoDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
Eleonora CandiDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.

Funding

Medical Research Council MC_U132670600Medical Research Council MC_UU_00025/2
6 · The paper itself

Abstract

Skin cancer is the most common type of cancer worldwide. Ozone depletion and climate changes might cause a further increase in the incidence rate in the future. Although the early detection of skin cancer enables it to be treated successfully, some tumours can evolve and become more aggressive, especially in the case of melanoma. Therefore, good diagnostic and prognostic markers are needed to ensure correct detection and treatment. Transcription factor p63, a member of the p53 family of proteins, plays an essential role in the development of stratified epithelia such as skin. In this paper, we conduct a comprehensive review of p63 expression in different types of skin cancer and discuss its possible use in the diagnosis and prognosis of cutaneous tumours.

Indexed as

Basal Cell CarcinomaBiomarkers, TumorCarcinoma, Squamous CellHumansImmunohistochemistryMelanomaPrognosisSkin NeoplasmsTranscription FactorsTumor Suppressor ProteinsBiomarkers, TumorTP63 protein, humanTranscription FactorsTumor Suppressor Proteinsbasal cell carcinomaMerkel cell carcinomap40p63skin cancersquamous cell carcinoma

Identifiers

PMID31744230
PMCPMC6888618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.