Evidence map›Paper›PMID 31744223›Full record

ArticleInternational journal of molecular sciences2019

The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT.

Kaja Karaś, Anna Sałkowska, Iwona Karwaciak, Aurelia Walczak-Drzewiecka, Jarosław Dastych, Rafał A Bachorz, Marcin Ratajewski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaja KaraśLaboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.ORCID 0000-0002-1790-698X
Anna SałkowskaLaboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.ORCID 0000-0002-3607-2888
Iwona KarwaciakLaboratory of Transcriptional Regulation, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.
Aurelia Walczak-DrzewieckaLaboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.
Jarosław DastychLaboratory of Cellular Immunology, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.
Rafał A BachorzLaboratory of Molecular Modeling, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.
Marcin RatajewskiLaboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.ORCID 0000-0001-5391-5843

Funding

Narodowe Centrum Nauki 2015/19/B/NZ7/03778
6 · The paper itself

Abstract

The

Indexed as

AcrylamidesAniline CompoundsAnimalsAnti-Inflammatory AgentsCell SurvivalCytokinesErbB ReceptorsHep G2 CellsHumansIndolesInflammationModels, MolecularMolecular Docking SimulationNuclear Receptor Subfamily 1, Group F, Member 3PhosphorylationPromoter Regions, GeneticAcrylamidesAniline CompoundsAnti-Inflammatory AgentsAZ5104CytokinesEGFR protein, humanErbB ReceptorsIndolesMAS1 protein, humanNuclear Receptor Subfamily 1, Group F, Member 3osimertinibProtein IsoformsProto-Oncogene MasPyrimidinesRORC protein, humanSmall Molecule LibrariesSTAT3 protein, humanSTAT3 Transcription FactorAZ5104EGFR (epidermal growth factor receptor)RORC (RAR related orphan receptor C)RORgamma (nuclear receptor ROR-gamma isoform 1)RORgammaT (nuclear receptor ROR-gamma isoform 1)Th17 (T helper 17 cell)

Identifiers

PMID31744223
PMCPMC6887705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.