Evidence map›Paper›PMID 31744219›Full record

ArticleNutrients2019

The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines.

Paola Ghanem, Annalise Zouein, Maya Mohamad, Mohammad H Hodroj, Tony Haykal, Sonia Abou Najem, Hassan Y Naim, Sandra Rizk

Abstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Role of reactive oxygen species in myelodysplastic syndromes.Cellular & molecular biology letters · 2024
    Review
  6. Review
  7. The Antioxidant and Proapoptotic Effects ofPlants (Basel, Switzerland) · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paola GhanemDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.
Annalise ZoueinDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.
Maya MohamadDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.
Mohammad H HodrojDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.
Tony HaykalDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.
Sonia Abou NajemDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.
Hassan Y NaimDepartment of Physiological Chemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Sandra RizkDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.

Funding

Lebanese American University SRDC
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines

Indexed as

AnimalsAntineoplastic AgentsApoptosisApoptosis Regulatory ProteinsCell Culture TechniquesCell CycleCell Line, TumorCell SurvivalChromansDNA FragmentationHumansLeukemia, Myeloid, AcuteMaleRatsRats, WistarReactive Oxygen SpeciesAntineoplastic AgentsApoptosis Regulatory ProteinsChromansplastochromanol 8Reactive Oxygen SpeciesVitamin Eapoptosisgamma tocotrienolsleukemiavitamin E

Identifiers

PMID31744219
PMCPMC6893610

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.