Evidence map›Paper›PMID 31744209›Full record

ReviewPlants (Basel, Switzerland)2019

The Suitability of Orthogonal Hosts to Study Plant Cell Wall Biosynthesis.

Markus Pauly, Niklas Gawenda, Christine Wagner, Patrick Fischbach, Vicente Ramírez, Ilka M Axmann, Cătălin Voiniciuc

Open access · goldAbstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Synthesis of Plant-InspiredACS synthetic biology · 2026
    Article
  2. Article
  3. Top five unanswered questions in plant cell surface research.Cell surface (Amsterdam, Netherlands) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Markus PaulyInstitute for Plant Cell Biology and Biotechnology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-3116-2198
Niklas GawendaInstitute for Plant Cell Biology and Biotechnology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Christine WagnerIndependent Junior Research Group-Designer Glycans, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany.
Patrick FischbachInstitute of Synthetic Biology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-2781-5264
Vicente RamírezInstitute for Plant Cell Biology and Biotechnology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0001-9786-497X
Ilka M AxmannInstitute for Synthetic Microbiology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Cătălin VoiniciucIndependent Junior Research Group-Designer Glycans, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany.ORCID 0000-0001-9105-014X
Heinrich Heine University Düsseldorf · DELeibniz Institute of Plant Biochemistry · DE

Funding

Deutsche Forschungsgemeinschaft 390686111Deutsche Forschungsgemeinschaft 414353267Deutsche Forschungsgemeinschaft ZU259/2-1
6 · The paper itself

Abstract

Plant cells are surrounded by an extracellular matrix that consists mainly of polysaccharides. Many molecular components involved in plant cell wall polymer synthesis have been identified, but it remains largely unknown how these molecular players function together to define the length and decoration pattern of a polysaccharide. Synthetic biology can be applied to answer questions beyond individual glycosyltransferases by reconstructing entire biosynthetic machineries required to produce a complete wall polysaccharide. Recently, this approach was successful in establishing the production of heteromannan from several plant species in an orthogonal host-a yeast-illuminating the role of an auxiliary protein in the biosynthetic process. In this review we evaluate to what extent a selection of organisms from three kingdoms of life (Bacteria, Fungi and Animalia) might be suitable for the synthesis of plant cell wall polysaccharides. By identifying their key attributes for glycoengineering as well as analyzing the glycosidic linkages of their native polymers, we present a valuable comparison of their key advantages and limitations for the production of different classes of plant polysaccharides.

Indexed as

cell wallsglycosyltransferasesheterologous expressionpolysaccharidessynthetic biology

Identifiers

PMID31744209
PMCPMC6918405
OpenAlexW2989376274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.